Substantial role of locus coeruleus-noradrenergic activation and capsaicin-insensitive primary afferent fibers in bee venom's anti-inflammatory effect

Neuroscience Research
Young-Bae KwonJang-Hern Lee

Abstract

Several lines of evidence indicate significant interactions between the immune and nervous systems. Our recent study reveals that 'bee venom (BV) induced anti-inflammatory effect' (BVAI) was produced by sympathetic preganglionic neuronal activation and subsequent adrenomedullary catecholamine release in a zymosan-induced inflammation model. However, the specific peripheral input and the supraspinal neuronal systems that are involved in this BVAI remain to be defined. Here we show that subcutaneous BV injection into left hind limb significantly reduces zymosan-induced leukocyte migration and that this effect is completely inhibited by denervation of the left sciatic nerve. This BVAI was not affected by the destruction of capsaicin-sensitive primary afferent fibers using either neonatal capsaicin or resiniferatoxin (RTX) pretreatment. BV injection into the left hind limb significantly increased Fos expression in the contralateral locus coeruleus (LC) in non-inflamed mice. In zymosan-inflamed mice, BV injection produced a further increase in LC Fos expression as compared with non-inflamed mice. This BV-induced Fos increase in the LC was not affected by RTX pretreatment. Pharmacological blockage of central noradrenergic activity by...Continue Reading

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Citations

Aug 30, 2013·Biological & Pharmaceutical Bulletin·Seo-Yeon YoonDae-Hyun Roh
Feb 6, 2010·Neurological Research·Young Bae KwonJang Hern Lee
Jan 31, 2016·BMC Complementary and Alternative Medicine·Bongjun SurDae-Hyun Hahm
Sep 13, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Suk-Yun KangJang-Hern Lee
Sep 10, 2019·Frontiers in Integrative Neuroscience·Qiuyi LvLanying Liu
Apr 3, 2021·Medical Oncology·Tenzin TenderHariharapura Raghu Chandrashekar
Jan 3, 2020·Complementary Medicine Research·Andrés Jagua-GualdrónRoger Edwin Fernadez-Bernal

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