Substantial spontaneous long-term remission in subacute sclerosing panencephalitis (SSPE)

Journal of the Neurological Sciences
B Santoshkumar, K Radhakrishnan

Abstract

We report a 25-year-old female who developed clinical and electroencephalographic (EEG) features of subacute sclerosing panencephalitis (SSPE) at the age of 17 years. After almost 17 months of progressive neurological deterioration to a level where she was bedridden and incapable of self-care (Risk and Haddad stage 3a), she experienced a substantial spontaneous clinical and EEG remission (stage 4c) which she has maintained for the last 8 years. The measles antibody titer in the cerebrospinal fluid (CSF), however, progressively increased during follow-up. There are only very few patients with well documented diagnosis of SSPE who have maintained such a prolonged remission. The age at onset of SSPE of > or = 12 years, disappearance of periodic complexes and a tendency for normalization of the background activity in the EEG, and a progressive increase in the measles antibody titer in the CSF appears to predict a favourable outcome of SSPE.

References

Jan 1, 1985·European Neurology·C CianchettiM Loi
Sep 1, 1966·Electroencephalography and Clinical Neurophysiology·W Cobb
May 1, 1970·The British Journal of Psychiatry : the Journal of Mental Science·J HimmelhochT Detre
May 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·C R Barraclough
Feb 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·W A CobbF Scaravilli
May 1, 1984·Annals of Neurology·N S KrawieckiA Swift
May 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·C H Wulff
Nov 1, 1996·Neurology·B AnlarK Yalaz
Nov 1, 1996·Electroencephalography and Clinical Neurophysiology·B Santoshkumar, K Radhakrishnan
May 1, 1956·Neurology·J F KURTZKE
Sep 5, 1964·British Medical Journal·J M PEARCE, D D BARWICK

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Citations

Jan 25, 2002·Postgraduate Medical Journal·R K Garg
Sep 12, 2008·Journal of the Neurological Sciences·Erdal ErogluZeki Odabasi
Mar 24, 2006·Brain & Development·L K PrashanthS Rao
Apr 2, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jelena Ivancic-JeleckiDubravko Forcic
Sep 23, 2016·Journal of the Neurological Sciences·Peter S SpencerUNKNOWN other Members of the Oregon-Uganda Nodding Syndrome Research Team
Dec 30, 2017·Indian Journal of Psychological Medicine·Ranjan BhattacharyyaSumita Bhattacharyya
Dec 10, 1999·Pediatrics·S Y Park, S Kohl

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