Substituted alpha-(phenylhydrazono)phenylacetonitrile derivatives. Part 1: A new class of uncoupler of oxidative phosphorylation

Pest Management Science
Peter DankoStephan Trah


Substituted alpha-(phenylhydrazono)phenylacetonitrile derivatives have been discovered which constitute a series of potent uncouplers of oxidative phosphorylation. Systematic variation of substituents on both benzene rings has clearly demonstrated the importance of steric congestion around the ionisation site and delocalisation of negative charge in the anionic form. Replacement of the cyano group by other electron-withdrawing groups leads to a dramatic decrease in uncoupling activity. The sub-nanomolar levels of uncoupling activity found in certain members indicate that these compounds are the most potent uncouplers yet reported.


Jul 1, 1990·Environmental Health Perspectives·H Terada
Jul 1, 1973·Journal of Agricultural and Food Chemistry·G KaugarsV L Rizzo
Jan 1, 1980·Pharmacology & Therapeutics·P G Heytler
Dec 30, 1981·Biochimica Et Biophysica Acta·H Terada

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Dec 2, 2017·Pest Management Science·Adam BurrissJürgen Schaetzer
Oct 5, 2012·Pest Management Science·André Jeanguenat

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