journal cover

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Bioorganic & Medicinal Chemistry

Jul 6, 2000

D MakheyE J LaVoie

PMID: 10882027

Abstract

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associate...read more

Mentioned in this Paper

Topoisomerase I Inhibitors
Acridine derivatives, antiseptics and disinfectants
Derivatives
benz(c)acridine
Heterocyclic Compounds
Coralyne
Poisoning Aspects
Cations
Topoisomerase
DNA Cleavage
Paper Details
References
  • References31
  • Citations16
1234
  • References31
  • Citations16
12
© 2020 Meta ULC. All rights reserved

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Bioorganic & Medicinal Chemistry

Jul 6, 2000

D MakheyE J LaVoie

PMID: 10882027

DOI:

Abstract

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associate...read more

Mentioned in this Paper

Topoisomerase I Inhibitors
Acridine derivatives, antiseptics and disinfectants
Derivatives
benz(c)acridine
Heterocyclic Compounds
Coralyne
Poisoning Aspects
Cations
Topoisomerase
DNA Cleavage

Related Papers

Paper Details
References
  • References31
  • Citations16
1234
  • References31
  • Citations16
12
/papers/substituted-benzaacridines-and-benzcacridines-as/10882027