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Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Bioorganic & Medicinal Chemistry

May 1, 2000

Darshan MakheyEdmond J. LaVoie

PMID: 10882027

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Abstract

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associate...read more

Mentioned in this Paper

Acridines
Alkaloids
Cations
Topoisomerase II
Enzyme Inhibitors
Heterocyclic Compounds
Pharmacology
Poisoning Aspects
benz(a)acridine
benz(c)acridine
Paper Details
References
    • References31
    • Citations14
    • References31
    • Citations14
  • Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

    Bioorganic & Medicinal Chemistry

    May 1, 2000

    Darshan MakheyEdmond J. LaVoie

    PMID: 10882027

    DOI:

    Abstract

    Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the presence of a positively charged iminium group, which has been postulated to be associate...read more

    Mentioned in this Paper

    Acridines
    Alkaloids
    Cations
    Topoisomerase II
    Enzyme Inhibitors

    Related Papers

    Paper Details
    References
    • References31
    • Citations14
    • References31
    • Citations14
  • Get paper from

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