Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection

Bioorganic & Medicinal Chemistry Letters
John F MillerPamela Golden

Abstract

The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.

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Citations

Jan 30, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aino E LaineAri M P Koskinen
Aug 1, 2021·European Journal of Medicinal Chemistry·Bo Luo, Xinqiang Song
Jul 28, 2018·Journal of Agricultural and Food Chemistry·Yuanqiong HuangQingmin Wang
Sep 4, 2021·European Journal of Medicinal Chemistry·Jiayun WangXin Chen

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