Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity

Diabetologia
L K M SummersK N Frayn

Abstract

British dietary recommendations are to decrease total fat intake to less than 30 % of daily energy intake and saturated fat to less than 10 %. In practice, it is difficult for people to make these changes. It may be easier to encourage people to switch from a diet rich in saturated fatty acids to one rich in polyunsaturated fatty acids. A total of 17 subjects - six people with Type II (non-insulin-dependent) diabetes mellitus, six non-obese and five obese people without diabetes - were randomised to spend two 5-week periods on a diet rich in saturated or in polyunsaturated fatty acids, in a crossover design. At the start of the study and after each dietary period, we assessed abdominal fat distribution using magnetic resonance imaging, insulin sensitivity using hyperinsulinaemic-euglycaemic clamps and fasting lipid parameters. Dietary compliance, assessed by weekly 3-day dietary records and measurement of biochemical markers, was good. Energy and fat intake appeared to be reduced on the diet rich in polyunsaturated fatty acids although body weights did not change. Insulin sensitivity and plasma low density lipoprotein cholesterol concentrations improved with the diet rich in polyunsaturated fatty acids compared with the diet ri...Continue Reading

Citations

Oct 25, 2002·Diabetes/metabolism Research and Reviews
Feb 4, 2010·Diabetologia·D IggmanU Risérus
Feb 26, 2010·Diabetologia·K N FraynF Karpe
Mar 5, 2005·Journal of the American Dietetic Association·Joyce A Nettleton, Robert Katz
Jul 5, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A A Rivellese, S Lilli
Jan 11, 2011·The British Journal of Nutrition·Simon G AndersonJ Kennedy Cruickshank
Apr 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H E PopeijusR P Mensink
Jun 19, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M SteffenA R Sinaiko
Oct 13, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C TierneyH M Roche
May 31, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E LarquéA Gil
Jul 3, 2004·The British Journal of Nutrition·M Parillo, G Riccardi
Nov 15, 2011·Journal of the American College of Nutrition·Graziela A KleinEdson L da Silva
Mar 1, 2012·Critical Reviews in Food Science and Nutrition·Chrystalleni LazarouAntonia-Leda Matalas
Jan 15, 2005·Current Opinion in Lipidology·Dawn Colleen Schwenke
Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Ulf Risérus
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Lindsay E RobinsonVera C Mazurak
Mar 12, 2005·Annual Review of Public Health·Matthias B Schulze, Frank B Hu
Jan 25, 2005·Cardiology·Robert GodefroiRobert J Goldberg
May 27, 2008·International Archives of Medicine·Shanmugam SivabalanVenugopal P Menon
Nov 17, 2010·Journal of Lipid Research·Junichi IshiyamaKoji Murakami
Oct 19, 2007·Journal of Cardiovascular Medicine·Walter C Willett
Feb 12, 2011·The American Journal of Clinical Nutrition·Lawrence de KoningFrank B Hu
Apr 2, 2010·The American Journal of Clinical Nutrition·Jina ChooUNKNOWN ERA-JUMP Study Group
Jan 8, 2014·Current Atherosclerosis Reports·Parag GoyalWilliam B Borden
Dec 24, 2013·European Journal of Nutrition·Sridevi Krishnan, Jamie A Cooper
Jun 11, 2014·Journal of Endocrinological Investigation·Ana PetelinZala Jenko-Pražnikar
May 7, 2014·Diabetes Research and Clinical Practice·Nathalie EsserNicolas Paquot

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.