Substitution between Aristolochia and Bryonia genus in North-Eastern Morocco: toxicological implications

Journal of Ethnopharmacology
Amal YamaniJoëlle Nortier

Abstract

Although acknowledged as toxic herbs, Aristolochia species are still widely used worldwide. The aristolochic acids (AA) they contain can induce the so-called "aristolochic acid nephropathy", leading to renal fibrosis and upper urinary tract cancer. Traditional Moroccan medicine still often uses Aristolochia species under the vernacular name of Bereztem for the treatment of numerous ailments, notably cancer, diabetes or digestive tract disorders. As the botanical identity and renal toxicity of used species remain unexplored, the safety of patients may be threatened. Ethnopharmacological data were collected from herbalists from the provinces of Oujda and Berkane, located in North-Eastern Morocco. Samples of Bereztem were collected at herbalist shops and checked for their content in AA using TLC and LC-MS methods. The toxicity of crude methanolic extracts of each herb was assessed on a HK-2 cell-based in vitro model by measurement of the cell survival to evaluate cytotoxicity and by assessment of renal-specific toxicity via (i) the evaluation of genes (E-cadherin and α-smooth muscle actin) expression by RT-qPCR; (ii) the quantities of β-catenin and vimentin by immunofluorescence microscopy; (iii) the secretion of fibronectin; and ...Continue Reading

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Citations

Dec 4, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Valérian BunelPierre Duez
Oct 31, 2015·Néphrologie & thérapeutique·Joëlle NortierJean-Louis Vanherweghem
Jul 12, 2017·Frontiers in Pharmacology·Jorge M Alves-SilvaLígia Salgueiro
Nov 7, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mohammed BourhiaNaima Khlil
Oct 7, 2020·Journal of Ethnopharmacology·Ilyass Alami Merrouni, Mostafa Elachouri

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