Substitution of Linoleic Acid for Other Macronutrients and the Risk of Ischemic Stroke

Stroke; a Journal of Cerebral Circulation
Stine K VenøKim Overvad

Abstract

Ischemic stroke is a major health problem worldwide, but the influence of dietary factors on stroke risk is not well known. This study aimed to investigate the risk of ischemic stroke and its subtypes with a higher intake from linoleic acid and a concomitant lower intake from saturated fatty acids, monounsaturated fatty acids, or glycemic carbohydrates. In the Danish prospective Diet, Cancer, and Health Study of 57 053 participants aged 50 to 64 years at baseline, information on diet was collected using a validated semiquantitative food frequency questionnaire. Information on ischemic stroke was obtained from the Danish National Patient Register, and cases were all validated and subclassified according to the TOAST (Trial of ORG 10172 in Acute Stroke Treatment) classification. Substitution of linoleic acid for saturated fatty acid, monounsaturated fatty acid, or glycemic carbohydrates was investigated in relation to the risk of ischemic stroke and subtypes. Cox proportional hazards regression was used to estimate the associations with ischemic stroke adjusting for appropriate confounders. During 13.5 years of follow-up 1879 participants developed ischemic stroke. A slightly lower risk of ischemic stroke was found with a 5% high...Continue Reading

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Citations

Jun 30, 2019·Nutrients·Stine Krogh VenøChristian Sørensen Bork
Sep 28, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Firoozeh Hosseini-EsfahaniFereidoun Azizi
Feb 16, 2021·Frontiers in Genetics·Ding YeYingying Mao
Mar 23, 2021·The Journal of Pharmacy and Pharmacology·Daniele La RussaDiana Amantea
Nov 2, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Monica C SerraAlice S Ryan

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