PMID: 9160858Apr 1, 1997Paper

Substitution of the selective serotonin reuptake inhibitors fluoxetine and paroxetine for the discriminative stimulus effects of ethanol in rats

Psychopharmacology
S MaurelJ De Vry

Abstract

Rats trained to discriminate ethanol (EtOH, 1 g/kg IP) from saline in a two-lever procedure completely generalized to the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and paroxetine. Substitution of fluoxetine was completely blocked by the selective 5-HT2A receptor antagonist MDL 100,907 and not affected by the selective 5-HT1A receptor antagonist WAY-100635. It is suggested that the previously reported effectiveness of SSRIs in reducing EtOH consumption could be based on similarities in discriminative stimulus effects of SSRIs and EtOH. Stimulation of 5-HT2A receptors may underlie these stimulus similarities and contribute to the EtOH intake-reducing effects of SSRIs.

Citations

May 21, 1998·European Journal of Pharmacology·M C Wolff, J D Leander
May 20, 1999·European Journal of Pharmacology·S MaurelR Schreiber
Sep 6, 2000·Pharmacology, Biochemistry, and Behavior·M C MhatreF A Holloway
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·M C MhatreF A Holloway
Feb 14, 2002·Drug and Alcohol Dependence·Michael S CousinsHarriet de Wit
Jan 26, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·R SchreiberJ De Vry
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·K T Szeliga, K A Grant
Jan 9, 2007·Pharmacology, Biochemistry, and Behavior·Stuart T LeonardPeter J Winsauer
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Oct 23, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin Zack, Constantine X Poulos
Jan 1, 2001·International Journal of Psychiatry in Clinical Practice·J G Rahola

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