PMID: 8587117Dec 1, 1995Paper

Substitution rates in hepatitis delta virus

Journal of Molecular Evolution
J Krushkal, W H Li

Abstract

Substitution rates were estimated for the coding and noncoding regions of the hepatitis delta virus (HDV). The estimated rates of synonymous substitution in HDV were lower than the rates of substitution at non-synonymous sites and in the noncoding region. HDV has lower synonymous substitution rates than the hepatitis C virus, though both are RNA viruses. The relatively low rate of synonymous substitution in HDV may be due to a strong preference of G and C nucleotides at third codon positions. Variation in substitution rate among HDV lineages may be correlated with the clinical development of the HDV-induced hepatitis. The phylogenetic tree inferred for 24 HDV strains reveals similarities between lineages isolated from the same geographic region.

Citations

Feb 16, 2007·Journal of Virology·Shen-Yung WangI-Jane Sheen
Feb 7, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E Shirvani-DastgerdiF Tacke
Dec 16, 2004·Journal of Molecular Evolution·Maria Anisimova, Ziheng Yang
Jan 6, 2021·Proceedings of the National Academy of Sciences of the United States of America·Laura M BergnerDaniel G Streicker
Jul 27, 2021·JHEP Reports : Innovation in Hepatology·Matin KohsarJulian Schulze Zur Wiesch

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