PMID: 2332048Apr 9, 1990

Substrate-dependent inhibition of protein kinase C by specific inhibitors

FEBS Letters
M JuncoL Boscá

Abstract

Protein kinase C (PKC) and its proteolysis-derived protein kinase independent of Ca2+ and phospholipids (PKM), were purified from rat brain. By using histone H1 and protamine as substrates, we assayed the effect of several inhibitors of PKC and PKM. The inhibition turned out to be dependent on both the nature of the kinase and the type of substrate assayed. These results may help to interpret the different responses elicited by PKC inhibitors in vivo.

References

Jun 1, 1989·European Journal of Biochemistry·R M Marais, P J Parker
Jan 1, 1989·Annual Review of Biochemistry·U KikkawaY Nishizuka
Jun 1, 1989·Trends in Pharmacological Sciences·U T Rüegg, G M Burgess
Mar 13, 1986·Biochemical and Biophysical Research Communications·T TamaokiF Tomita
Jun 30, 1987·Biochemical and Biophysical Research Communications·J S Rush, C J Waechter
Jul 15, 1987·Biochemical and Biophysical Research Communications·M D Bazzi, G L Nelsestuen
Nov 30, 1984·Biochemical and Biophysical Research Communications·S Kawamoto, H Hidaka

Citations

Jan 26, 1995·Molecular and Cellular Biochemistry·R H Bruins, R M Epand
Dec 1, 1990·Trends in Pharmacological Sciences·L BoscáM J Díaz-Guerra
Feb 13, 1992·European Journal of Pharmacology·R LeursH Timmerman
Jun 22, 1999·European Journal of Pharmacology·V A EdgarA M Genaro

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