Substrate-Driven Transient Self-Assembly and Spontaneous Disassembly Directed by Chemical Reaction with Product Release

Journal of the American Chemical Society
Huaxin WangMyongsoo Lee

Abstract

The chemical reactivity of molecules can be significantly enhanced when they are trapped in a confined space. Although such a confinement effect can be found in many self-assembled nanostructures, dissipation after completing the reaction to release the product remains elusive. Here we report substrate-directed transient self-assembly for accelerating a chemical reaction and spontaneous disassembly with releasing the products. The hydrophobic substrates mediate self-assembly of a dissolved pyridine-based amphiphile to provide a confined space to promote an aromatic nucleophilic substitution (SNAr) reaction in water. The chemical reaction triggers disassembly of the aggregates with simultaneous release of the product that can be spontaneously separated out of the solution by precipitation. Neutralization of the amphiphilic molecule leads to a new cycle of self-assembly entrapping substrates and disassembly with releasing the product.

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Citations

Feb 18, 2020·Advanced Materials·Nishant SinghThomas M Hermans
Nov 7, 2019·Chemical Communications : Chem Comm·Payel DowariDebapratim Das
Apr 19, 2020·Nature Nanotechnology·Angela B GrommetRafal Klajn
Nov 3, 2020·Chemistry, an Asian Journal·Rahul Dev MukhopadhyayKimoon Kim
Jan 23, 2021·Chemistry : a European Journal·Oliver Fischer, Markus R Heinrich
Mar 9, 2021·Angewandte Chemie·Xinlong Fan, Andreas Walther
Dec 18, 2019·Chemical Science·Maria A Cardona, Leonard J Prins
May 18, 2021·Chemical Communications : Chem Comm·Xianhua LangChangsheng Zhao
Jun 15, 2021·Chemical Science·Carlo Bravin, Christopher A Hunter
Aug 6, 2021·Journal of the American Chemical Society·Enzo OlivieriAdrien Quintard
Dec 6, 2019·ACS Applied Materials & Interfaces·Shikha DhimanSubi J George
Jan 22, 2020·ACS Applied Materials & Interfaces·Yuanbo ZhongXu Wang

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