Substrate mediated redox partner selectivity of cytochrome P450

Chemical Communications : Chem Comm
Katherine A GentryAyyalusamy Ramamoorthy

Abstract

Investigating the interplay between cytochrome-P450 and its redox partners (CPR and cytochrome-b5) is vital for understanding the metabolism of most hydrophobic drugs. Dynamic structural interactions with the ternary complex, with and without substrates, captured by NMR reveal a gating mechanism for redox partners to promote P450 function.

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Citations

Jun 5, 2018·Chemical Communications : Chem Comm·Carlo BarnabaAyyalusamy Ramamoorthy
Dec 4, 2020·The Journal of Steroid Biochemistry and Molecular Biology·E O YablokovN V Strushkevich
Dec 30, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Thirupathi Ravula, Ayyalusamy Ramamoorthy

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Methods Mentioned

BETA
NMR

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