Substrate, product, and cofactor: The extraordinarily flexible relationship between the CDE superfamily and heme

Archives of Biochemistry and Biophysics
Arianna I Celis, Jennifer L DuBois

Abstract

PFam Clan 0032, also known as the CDE superfamily, is a diverse group of at least 20 protein families sharing a common α,β-barrel domain. Of these, six different groups bind heme inside the barrel's interior, using it alternately as a cofactor, substrate, or product. Focusing on these six, an integrated picture of structure, sequence, taxonomy, and mechanism is presented here, detailing how a single structural motif might be able to mediate such an array of functions with one of nature's most important small molecules.

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Citations

Jun 18, 2015·Biochemistry·Arianna I CelisJennifer L DuBois
Apr 20, 2016·BMC Bioinformatics·Giriraj AcharyaSrikrishna Subramanian
Mar 10, 2015·Archives of Biochemistry and Biophysics·Irene SchaffnerChristian Obinger
Jan 27, 2017·Microbiology and Molecular Biology Reviews : MMBR·Harry A DaileyMartin J Warren
May 8, 2019·Molecular Microbiology·Justin ClarkAnthony Maresso
Feb 10, 2016·Bioscience Reports·Stefan HofbauerChristian Obinger
Sep 7, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Stefan HofbauerPaul G Furtmüller
Sep 3, 2021·Biological Reviews of the Cambridge Philosophical Society·Luděk KořenýJulius Lukeš

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