May 11, 2019

Substrate selection by the proteasome through initiation regions

Protein Science : a Publication of the Protein Society
Takuya Tomita, A Matouschek


Proteins in the cell have to be eliminated once their function is no longer desired or they become damaged. Most regulated protein degradation is achieved by a large enzymatic complex called the proteasome. Many proteasome substrates are targeted for degradation by the covalent attachment of ubiquitin molecules. Ubiquitinated proteins can be bound by the proteasome, but for proteolysis to occur the proteasome needs to find a disordered tail somewhere in the target at which it initiates degradation. The initiation step contributes to the specificity of proteasomal degradation. Here, we review how the proteasome selects initiation sites within its substrates and discuss how the initiation step affects physiological processes.

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Mentioned in this Paper

Ubiquitinated Proteins
Regulation of Protein Catabolic Process
Physiological Aspects
Multicatalytic endopeptidase complex
Physiological Processes
Ubiquitin, Human
Ubiquitin, Human

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