Substrate utilization during and after exercise in mild cystic fibrosis.

Medicine and Science in Sports and Exercise
Laurie WidemanMichael S Schechter

Abstract

To determine substrate utilization and energy expenditure during maximal and submaximal exercise and recovery in adolescents with cystic fibrosis (CF) and healthy age-matched controls (C). Ten clinically stable CF patients (four girls, six boys; age = 10-22 yr) were matched by body mass index, age, gender, and Tanner stage to healthy controls. Subjects completed VO(2peak) testing and submaximal exercise (20 min) on a cycle ergometer at a relative intensity of 50% VO2(peak) and at an absolute power output (PO). Metabolic parameters were assessed during exercise and recovery (20 min). Similar respiratory quotient (RQ) values occurred in both groups during maximal exercise and recovery, despite differences in the maximal PO [CF = 114 (60-180) W and C = 171 (105-280) W, P = 0.006], the total work completed [CF = 27 (9.0-54.3) kJ and C = 55 (25.3-126.5) kJ, P = 0.008], or the VO(2peak) value attained [CF = 30.6 (8.5-45.2) mL kg(-1) min(-1) and C = 40.6 (29-64.5) mL kg(-1) min(-1), P = 0.027]. Submaximal exercise at the same absolute PO resulted in similar RQ values during exercise and recovery despite higher heart rates and average VO2 [CF = 18.8 (9.3-28.7) mL kg(-1) min(-1) and C = 15.2 (6.5-20.1) mL kg(-1)min(-1), P = 0.031] value...Continue Reading

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Citations

Sep 23, 2011·European Journal of Applied Physiology·Justin BlandJoey C Eisenmann
Jul 3, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Thanh NguyenBrian W Timmons
Feb 10, 2011·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Maarten S WerkmanTim Takken
Apr 22, 2010·Expert Review of Respiratory Medicine·Fidelma Moran, Judy Bradley
Jun 19, 2019·American Journal of Physiology. Endocrinology and Metabolism·Nicola LaiCharles Hoppel
Nov 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Daniel StevensCraig A Williams

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