Substrate utilization during submaximal exercise in children with a severely obese parent.

Nutrition & Metabolism
Audrey D EavesJoseph A Houmard

Abstract

We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inherent component. The purpose of the current study was to determine if an impairment in whole-body fatty acid oxidation (FAO) was also evident in children with a severely obese parent. Substrate utilization during submaximal exercise (cycle ergometer) was determined in children ages 8-12 y with a severely obese parent (OP, n = 13) or two lean/non-obese (BMI range of 18 to 28 kg/m2) parents (LP, n = 13). A subgroup of subjects (n = 3/group) performed 4 weeks of exercise training with substrate utilization measured after the intervention. The children did not differ in age (LP vs. OP, respectively) (10.7 ± 0.5 vs. 10.2 ± 0.5 y), BMI percentile (65.3 ± 5.2 vs. 75.9 ± 7), Tanner Stage (1.4 ± 0.2 vs. 1.5 ± 0.2), VO2peak (40.3 ± 2.7 vs. 35.6 ± 2.6 ml/kg/min) or physical activity levels (accelerometer). At the same absolute workload of 15 W (~38% VO2peak), RER was significantly (P ≤ 0.05) lower in LP vs. OP (0.83 ± 0.02 vs. 0.87 ± 0.01) which was reflected in a reduced reliance on FAO for energy production in the OP group (58.6 ...Continue Reading

References

Sep 26, 1997·The New England Journal of Medicine·R C WhitakerW H Dietz
Mar 25, 2000·The American Journal of Clinical Nutrition·M S TreuthW W Wong
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·J Y KimJ A Houmard
Feb 22, 2001·Journal of Applied Physiology·N R GuesbeckJ A Houmard
Apr 5, 2002·Medicine and Science in Sports and Exercise·Robert L MirwaldGaston P Beunen
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Matthew W HulverJoseph A Houmard
Dec 12, 2003·The American Journal of Clinical Nutrition·Margarita S TreuthJohn D Sorkin
Feb 19, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R GiaccoG Riccardi
Jul 6, 2004·Medicine and Science in Sports and Exercise·Jason R BerggrenJoseph A Houmard
Jul 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·John P ThyfaultG Lynis Dohm
Feb 3, 2005·Obesity Research·Tatiana AndreyevaJeanne S Ringel
Apr 3, 2007·Public Health·R Sturm
Sep 1, 2007·Medicine and Science in Sports and Exercise·Michelle M YoreCaroline A Macera
Nov 21, 2007·Pediatric Exercise Science·Ann V Rowlands
Dec 18, 2007·Pediatrics·Nancy F KrebsDennis Styne
Feb 7, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jason R BerggrenJoseph A Houmard
Mar 28, 2008·Pediatric Exercise Science·Sigurbjorn Arni ArngrimssonErlingur Jóhannsson
Mar 25, 2009·American Journal of Human Biology : the Official Journal of the Human Biology Council·Clemens DrenowatzDavid Walsh
Oct 12, 2010·Current Diabetes Reports·Blanca M Herrera, Cecilia M Lindgren

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Citations

Mar 29, 2018·The Journal of Sports Medicine and Physical Fitness·David ThivelJulien Aucouturier
Mar 4, 2020·International Journal of Molecular Sciences·Avigdor D AradFred J DiMenna

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Methods Mentioned

BETA
gastric bypass

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