PMID: 8950312Jan 1, 1996Paper

Substrates for hypothalamic PGE2 synthesis are not decreased in cholestatic rats

Life Sciences
M G Swain, J B Meddings

Abstract

We have recently described impaired IL-1 beta-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis in cholestatic rats and have implicated defective IL-1 beta-mediated hypothalamic generation of PGE2 in this finding. Since patients with obstructive cholestasis have decreased levels of PGE2 precursor fatty acids in their red blood cell membranes (arachidonic acid) we speculated that a similar deficiency of membrane prostaglandin percursor fatty acids in the hypothalamus of cholestatic rats may contribute to the defective cytokine-mediated PGE2 generation we have previously described. Therefore, in this study we determined red blood cell and hypothalamic membrane fatty acid composition in rats with obstructive cholestasis due to bile duct resection and in non-cholestatic sham resected controls 5 days after operation. To do this red blood cell membrane and hypothalamic membrane fatty acids were extracted, methyl esterified and quantified by gas liquid chromatography. Similar to results found in patients with obstructive cholestasis, bile duct resected rats had significantly reduced levels of red blood cell membrane arachidonic acid compared to levels in sham resected controls (p < or = 0.02). However, bile duct rese...Continue Reading

References

Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Aug 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J GoetzlW L Smith
Oct 21, 1993·The New England Journal of Medicine·S Reichlin

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