Mar 1, 1976

Subsynaptosomal distribution, inhibition, and characterization of the binding of (14C) 5-OH-indole-3-acetaldehyde to brain preparations

Research Communications in Chemical Pathology and Pharmacology
F Ungar, S G Alivisatos

Abstract

The distribution of the monoamine oxidase (MAO) dependent binding of [14C] serotonin as well as of pre-formed [14C] 5-OH-indole-3-acetaldehyde to synaptic subfractions paralleled the gross distribution of MAO. The binding of [14C] serotonin and MAO activity in brain preparations was inhibited by CNS antidepressants (imipramine) or stimulants (caffeine), by hallucinogens (N,N-dimethyltryptamine), sedatives (chlorpromazine), and other drugs. The protein-lipid nature of the binding macromolecule was determined. The chemical nature of the acceptors was also investigated. Experiments with sodium borohydride indicated the partial formation of imines, those with SH-reactive compounds showed partial involvement of acceptor-SH groups in the binding.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Phenoxybenzamine Hydrochloride
Borohydrides
Brain
Sulfhydryl Compounds
Receptors, Drug
Monoamine Oxidase
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Thymoleptics
Synaptic Membranes
Hydroxyindoleacetic Acid

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

Related Papers

Research Communications in Chemical Pathology and Pharmacology
F UngarS G Alivisatos
The Journal of Clinical Psychiatry
C T Gaultieri, S F Powell
Research Communications in Chemical Pathology and Pharmacology
F Ungar, O H Callaghan
© 2020 Meta ULC. All rights reserved