Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use

Molecular Psychiatry
Yann PellouxChristelle Baunez

Abstract

One of the key features of addiction is the escalated drug intake. The neural mechanisms involved in the transition to addiction remain to be elucidated. Since abnormal neuronal activity within the subthalamic nucleus (STN) stands as potential general neuromarker common to impulse control spectrum deficits, as observed in obsessive-compulsive disorders, the present study recorded and manipulated STN neuronal activity during the initial transition to addiction (i.e., escalation) and post-abstinence relapse (i.e., re-escalation) in rats with extended drug access. We found that low-frequency (theta and beta bands) neuronal oscillations in the STN increase with escalation of cocaine intake and that either lesion or high-frequency stimulation prevents the escalation of cocaine intake. STN-HFS also reduces re-escalation after prolonged, but not short, protracted abstinence, suggesting that STN-HFS is an effective prevention for relapse when baseline rates of self-administration have been re-established. Thus, STN dysfunctions may represent an underlying mechanism for cocaine addiction and therefore a promising target for the treatment of addiction.

References

Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
Aug 1, 1994·Journal of Neurophysiology·H BergmanM R DeLong
Jan 8, 1998·The European Journal of Neuroscience·Christelle Baunez, T W Robbins
May 23, 2002·Brain : a Journal of Neurology·Ron LevyJonathan O Dostrovsky
Jun 11, 2002·Nature Neuroscience·Serge H AhmedAthina Markou
Jun 29, 2004·Pharmacology, Biochemistry, and Behavior·Megan E Roth, Marilyn E Carroll
Aug 18, 2004·Science·Louk J M J Vanderschuren, Barry J Everitt
Mar 29, 2005·Nature Neuroscience·Christelle BaunezMarianne Amalric
Jul 14, 2005·Neuroreport·Yassine DarbakyPaul Apicella
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bertrand DegosNicolas Maurice
Aug 27, 2005·Brain : a Journal of Neurology·Wassilios MeissnerThomas Boraud
Oct 9, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Sunmee WeeGeorge F Koob
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MalletPeter J Magill
Aug 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fair M VassolerR Christopher Pierce
Nov 14, 2008·The New England Journal of Medicine·L MalletSTOC Study Group
Aug 28, 2009·Journal of Neurophysiology·Sylvie LardeuxChristelle Baunez
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tiphaine RouaudChristelle Baunez
Sep 14, 2010·Trends in Neurosciences·Paul KrackJose A Obeso
Aug 26, 2011·Neuroscience·Serge H Ahmed
Sep 21, 2011·Molecular Psychiatry·J LuigjesD Denys
Oct 21, 2011·Frontiers in Systems Neuroscience·Christelle Baunez, Sylvie Lardeux
Jan 1, 2011·Translational Psychiatry·M-L WelterFrench Stimulation dans Trouble Obsessionnel Compulsif (STOC) Study Group
Mar 1, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Alexandre EusebioJean-Philippe Azulay
Mar 30, 2013·Current Opinion in Neurobiology·Yann Pelloux, Christelle Baunez
Jul 19, 2013·Journal of Neurophysiology·Sylvie LardeuxChristelle Baunez
Apr 10, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Julius HueblAndrea A Kühn
Dec 30, 2014·Frontiers in Behavioral Neuroscience·Yann PellouxChristelle Baunez
Apr 14, 2015·Nature Neuroscience·Coralie de HemptinnePhilip A Starr
May 1, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claire DelavilleJudith R Walters
May 20, 2015·Neurobiology of Disease·Sabira Hachem-DelaunayCatherine Le Moine
May 18, 2016·Brain : a Journal of Neurology·Alexandre ZénonAlexandre Eusebio
Dec 6, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carrie L WadeOlivier George

Citations

Jan 14, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Yvan VachezSabrina Boulet
Jul 7, 2020·The European Journal of Neuroscience·Emmanuel BreysseChristelle Baunez
Nov 18, 2018·Psychopharmacology·Maria Teresa De LucaAldo Badiani
Dec 18, 2020·Frontiers in Human Neuroscience·Yvan M Vachez, Meaghan Creed
Mar 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mickael DegouletYann Pelloux
Jan 4, 2020·Journal of Neuroscience Methods·Houyam TibarAbdelhamid Benazzouz

Related Concepts

Cocaine
Neurons
Obsessive-Compulsive Disorder
Self Administration
Drug Delivery Systems
Addictive Behavior
Band Form
Cocaine Dependence
Brain Waves
Drug Interactions

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.