Subthalamic nucleus or internal pallidal stimulation in young onset Parkinson's disease

Brain : a Journal of Neurology
P KrackA L Benabid

Abstract

The aim of this study was to compare, retrospectively, the value of chronic bilateral stimulation of the internal globus pallidus (GPi) and the subthalamic nucleus (STN) in patients with young onset Parkinson's disease. We selected 13 consecutive patients with similar characteristics at the time of surgery: age at onset < 40 years, disabling motor fluctuations (Hoehn and Yahr stage 4 or 5 in off-drug phases) and levodopa-induced dyskinesias (LID). Eight patients were operated on in the STN and five in the GPi. The Unified Parkinson's Disease Rating Scale (UPDRS), timed motor tests and a LID scale were compared in on- and off-drug conditions before surgery and 6 months after surgery on stimulation using the chronic electrical parameters found to improve best the motor state of the individual patient, without adverse effects. In off-drug phases, the motor score of the UPDRS was improved by 71% with STN stimulation and by 39% with GPi stimulation on average. This difference was statistically significant (P < 0.05). Whereas rigidity and tremor showed good improvement in both groups, the decrease in the akinesia score was more pronounced in the STN group. In the STN group, the improvement of all motor symptoms was very close, or equ...Continue Reading

Citations

Apr 22, 1999·Annals of Neurology·R G BrownJ C Rothwell
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·H R SiebnerF Alesch
Sep 29, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E LugingerW Poewe
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·C DromeyA M Lozano
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Franck DurifGérard Dordain
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJerry Vitek
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Pierre PollakAlim-Louis Benabid
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Anthony E Lang, Hakan Widner
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackPierre Pollak
Aug 2, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·T TrottenbergA Kupsch
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·N AllertH J Freund
Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P KrackA L Benabid
Oct 20, 1999·Journal of Neurology·P Limousin-DowseyA Benabid
Apr 11, 2009·Der Nervenarzt·R HilkerUNKNOWN German Deep Brain Stimulation Association
May 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Thomas J FeuersteinAndreas Moser
Mar 10, 2006·Experimental Brain Research·Dennis A Nowak, Joachim Hermsdörfer
Apr 12, 2006·Journal of Neurology·D DrapierB Millet
Feb 16, 2008·Journal of Neurology·Jasper E VisserBastiaan R Bloem
Feb 27, 2009·Journal of Neurology·Hélène Gervais-BernardStéphane Thobois
Aug 31, 2010·Journal of Neurology·Hans-Holger CapelleJoachim K Krauss
Aug 24, 2004·Cell and Tissue Research·Sorin BreitAlim-Louis Benabid
Dec 14, 2011·Journal of Neural Transmission·Francesca Di BiasioStefano Ruggieri
Oct 22, 2008·Medical & Biological Engineering & Computing·Mattias AströmKarin Wårdell
Mar 20, 2002·Current Neurology and Neuroscience Reports·J Hammerstad, P Hogarth
Jun 26, 2004·Current Neurology and Neuroscience Reports·Kelly E Lyons, Rajesh Pahwa
Jul 10, 2007·Current Neurology and Neuroscience Reports·Atchar SudhyadhomMichael S Okun
Jan 28, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ritsuko HanajimaPeter Ashby
Mar 31, 2004·Journal of the Neurological Sciences·Martin KrauseVolker Tronnier
Apr 9, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Patricia Limousin, Irene Martinez-Torres
Mar 23, 2004·Sleep Medicine·Raffaele ManniClaudio Pacchetti
Mar 19, 2002·Journal of the Neurological Sciences·Leonardo LopianoMichele Lanotte
Sep 29, 1999·Journal of the Neurological Sciences·W C KollerA Albanese
May 9, 2003·Brain and Language·Michèle GentilAlim-Louis Benabid
Oct 19, 2000·Archives of Medical Research·A L BenabidP Pollak

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