Subthalamic nucleus stimulation and lesioning have distinct state-dependent effects upon striatal dopamine metabolism

Synapse
Ruth H WalkerCharles K Meshul

Abstract

The mechanism by which deep brain stimulation (DBS) of the subthalamic nucleus (STN) achieves its effects in Parkinson's disease (PD) is not known. In animal models of PD, stimulation and lesioning of the STN have some effects which are the same, but others which differ, in reversing cellular and behavioral changes induced by dopamine depletion. We compared the effects of short-term STN stimulation and lesions upon extracellular levels of dopamine and metabolites using in vivo microdialysis of the dorsal striatum of awake, intact and unilateral 6-hydroxydopamine (6OHDA)-lesioned rats. STN stimulation in control rats decreased striatal dopamine levels and caused a relative increase in dopamine metabolism, as expressed by HVA/dopamine and DOPAC/dopamine ratios. This suggests an increase in both vesicular dopamine release (metabolized to HVA), and release from the cytoplasmic dopamine pool (metabolized to DOPAC). STN lesions in control rats increased the HVA/dopamine ratio, also suggesting a relative increase in vesicular dopamine release. These results indicate that STN stimulation and lesioning can affect striatal dopamine metabolism in the intact system. In 6OHDA-lesioned rats at baseline, metabolic ratios were markedly decreas...Continue Reading

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Citations

Nov 12, 2013·Journal of Neurosurgery·Vincent A JourdainThérèse Di Paolo
Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
Apr 14, 2011·The Journal of Physiology·Fang ZhengChristian Alzheimer
Dec 18, 2020·Frontiers in Human Neuroscience·Yvan M Vachez, Meaghan C Creed
Aug 31, 2014·Experimental Neurology·Vincent A JourdainThérèse Di Paolo

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