Subthalamic Nucleus Visualization on Routine Clinical Preoperative MRI Scans: A Retrospective Study of Clinical and Image Characteristics Predicting Its Visualization

Stereotactic and Functional Neurosurgery
Manish RanjanAndres M Lozano

Abstract

The visualization of the subthalamic nucleus (STN) on magnetic resonance imaging (MRI) is variable. Studies of the contribution of patient-related factors and intrinsic brain volumetrics to STN visualization have not been reported previously. To assess the visualization of the STN during deep brain stimulation (DBS) surgery in a clinical setting. Eighty-two patients undergoing pre-operative MRI to plan for STN DBS for Parkinson disease were retrospectively studied. The visualization of the STN and its borders was assessed and scored by 3 independent observers using a 4-point ordinal scale (from 0 = not seen to 3 = excellent visualization). This measure was then correlated with the patients' clinical information and brain volumes. The mean STN visualization scores were 1.68 and 1.63 for the right and left STN, respectively, with a good interobserver reliability (intraclass correlation coefficient: 0.744). Older age and decreased white matter volume were negatively correlated with STN visualization (p < 0.05). STN visualization is only fair to good on routine MRI with good concordance of interindividual rating. Advancing age and decreased white matter are associated with poor visualization of the STN. Knowledge about factors cont...Continue Reading

References

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Aug 22, 2015·Journal of Neurosurgery·Arjun S ChandranChristopher R P Lind
Aug 12, 2016·Frontiers in Neuroinformatics·José V Manjón, Pierrick Coupé

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Citations

May 20, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Luka MilosevicAlireza Gharabaghi
May 31, 2019·Current Neurology and Neuroscience Reports·Alexandre BoutetAlfonso Fasano

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