Subthalamic-pallidal interactions are critical in determining normal and abnormal functioning of the basal ganglia

Proceedings. Biological Sciences
A GilliesZhaoping Li

Abstract

The subthalamic nucleus (STN) and external globus pallidus (GP) form a recurrent excitatory-inhibitory interaction within the basal ganglia. Through a computational model of these interactions we show that, under the influence of appropriate external input, the two nuclei can be switched between states of high and low activity or can generate oscillations consisting of bursts of high-frequency activity repeated at a low rate. It is further demonstrated from the model that the generation of the repetitive bursting behaviour is favoured by increased inhibition of the GP, which is a condition indicated in Parkinson's disease. Paradoxically, increased striatal inhibition of the GP is predicted to cause an increase rather than a decrease in its mean firing rate. These behaviours, arising from a biologically inspired computational model of the STN-GP interaction, have important consequences for basal ganglia function and dysfunction.

References

Apr 18, 1979·Journal of Mathematical Biology·G B Ermentrout, J D Cowan
Dec 1, 1978·The Journal of Comparative Neurology·N Iwahori
Jan 1, 1990·Journal of Mathematical Biology·L Edelstein-Keshet, G B Ermentrout
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jun 1, 1985·The Journal of Comparative Neurology·S Afsharpour
Apr 4, 1983·Brain Research·H KitaS T Kitai
Apr 10, 1983·The Journal of Comparative Neurology·H KitaS T Kitai
Sep 1, 1994·Journal of Neurophysiology·A Nambu, R Llinaś
Aug 1, 1994·Journal of Neurophysiology·H BergmanM R DeLong
Jun 26, 1998·Journal of Neurophysiology·D G Beiser, J C Houk
Oct 1, 1998·Neurobiology of Learning and Memory·A M Graybiel
Dec 8, 1998·Proceedings. Biological Sciences·A J Gillies, D J Willshaw
Jun 11, 1999·Neuroscience·P RedgraveK Gurney
Aug 24, 1999·Nature·T Wichmann, M R DeLong
Aug 18, 2000·The European Journal of Neuroscience·C M Magariños-AsconeA Córdoba-Fernández
Jul 1, 1995·Journal of Cognitive Neuroscience·P DomineyJ P Joseph

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Citations

Nov 16, 2010·Nature Neuroscience·C Savio ChanD James Surmeier
Dec 17, 2004·Network : Computation in Neural Systems·K N GurneyP Redgrave
Apr 5, 2008·Neural Computation·Garipelli GangadharV Srinivasa Chakravarthy
Aug 16, 2013·Journal of Mathematical Neuroscience·Robert Merrison-HortRoman Borisyuk
Nov 12, 2003·Journal of Neurosurgery·Maja TrostDavid Eidelberg
Aug 28, 2012·Experimental Neurology·Edward Stein, Izhar Bar-Gad
Dec 18, 2013·The Journal of Physiology·Alejo J Nevado-HolgadoRafal Bogacz
Nov 14, 2015·Experimental Brain Research·Alain RíosEnrique Querejeta
Mar 6, 2012·Neural Networks : the Official Journal of the International Neural Network Society·Sanjeeva K KalvaNeelima Gupte
Jul 6, 2011·Neural Networks : the Official Journal of the International Neural Network Society·R KrishnanM Rengaswamy
Jan 22, 2009·Journal of Theoretical Biology·S J van AlbadaP A Robinson
May 10, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adriana Galvan, Thomas Wichmann
Jul 19, 2012·The European Journal of Neuroscience·Alex PavlidesRafal Bogacz
Feb 22, 2014·IEEE Transactions on Bio-medical Engineering·Clare Muireann DavidsonMadeleine M Lowery
Nov 27, 2004·Medical Engineering & Physics·A Gillies, D Willshaw
Jul 24, 2004·Trends in Neurosciences·Kevin GurneyPeter Redgrave
Nov 17, 2012·NeuroImage·André C MarreirosPeter Brown
Jun 16, 2015·Frontiers in Neuroscience·Alekhya MandaliAhmed A Moustafa
Jul 29, 2009·Neural Networks : the Official Journal of the International Neural Network Society·Reinoud Maex, Volker Steuber
Dec 17, 2014·Frontiers in Computational Neuroscience·Martin EbertPeter A Tass
May 12, 2006·International Journal of Neural Systems·D SridharanV S Chakravarthy
Oct 27, 2015·PLoS Computational Biology·Mingming ChenDezhong Yao
Mar 24, 2017·The Journal of Physiology·Alexander BlenkinsopKevin Gurney
Mar 21, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Sabato SantanielloSridevi V Sarma
Jun 12, 2018·International Journal of Neural Systems·Michael Caiola, Mark H Holmes
Sep 14, 2007·Expert Review of Medical Devices·Andrew Gillies, David Willshaw
Nov 22, 2019·Frontiers in Computational Neuroscience·Lucas A Koelman, Madeleine M Lowery
Apr 1, 2020·Cognitive Neurodynamics·Pragathi Priyadharsini Balasubramani, V Srinivasa Chakravarthy
Apr 9, 2019·Cognitive Neurodynamics·Bing HuLiqing Zong
Mar 27, 2020·Frontiers in Human Neuroscience·Nada YousifRoman Borisyuk
Aug 22, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Bernadette C M van WijkBirte U Forstmann
Nov 24, 2020·Applied Mathematics and Mechanics·Ying YuQingyun Wang
Dec 19, 2020·Neural Plasticity·Yaqian ChenMuhammad Bilal Ghori
Sep 11, 2017·Current Opinion in Neurobiology·Jonathan E Rubin
Apr 7, 2021·Journal of Neural Engineering·Benoit DuchetRafal Bogacz
Aug 22, 2018·NeuroImage·Bernadette C M van WijkKarl J Friston

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