Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro.

The Journal of Physiology
Ke-Zhong Shen, Steven W Johnson

Abstract

The subthalamic nucleus (STN) plays an important role in movement control by exerting its excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of the basal ganglia. Moreover, excessive burst firing of SNR neurons seen in Parkinson's disease has been attributed to excessive transmission in the subthalamonigral pathway. Using the 'blind' whole-cell patch clamp recording technique in rat brain slices, we found that focal electrical stimulation of the STN evoked complex, long-duration excitatory postsynaptic currents (EPSCs) in SNR neurons. Complex EPSCs lasted 200-500 ms and consisted of an initial monosynaptic EPSC followed by a series of late EPSCs superimposed on a slow inward shift in holding current. Focal stimulation of regions outside the STN failed to evoke complex EPSCs. The late component of complex EPSCs was markedly reduced by ionotropic glutamate receptor antagonists (2-amino-5-phosphonopentanoic acid and 6-cyano-7-nitro-quinoxalone) and by a GABAA receptor agonist (isoguvacine) when these agents were applied directly to the STN using a fast-flow microapplicator. Moreover, the complex EPSC was greatly enhanced by bath application of the GABAA receptor antagonists picrotoxin or b...Continue Reading

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Citations

Dec 31, 2009·Biological cybernetics·George L TsirogiannisKonstantina S Nikita
Jul 13, 2012·Journal of Neurophysiology·Michael A Farries, Charles J Wilson
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian R LeeMargaret E Rice
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shengyuan DingFu-Ming Zhou
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Sep 27, 2018·Journal of Neurophysiology·Verónica Alejandra Cáceres-ChávezJosé Bargas

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