Subtherapeutic Infliximab Trough Levels and Complete Mucosal Healing Are Associated With Sustained Clinical Remission After Infliximab Cessation in Paediatric-onset Crohn's Disease Patients Treated With Combined Immunosuppressive Therapy

Journal of Crohn's & Colitis
Ben KangYon Ho Choe

Abstract

We aimed to investigate the outcome in paediatric-onset Crohn's disease patients who had discontinued infliximab after maintaining clinical remission with combined immunosuppression, and to determine factors associated with clinical relapse. We conducted a retrospective observational study of 63 paediatric-onset Crohn's disease patients who had stopped scheduled infliximab during sustained corticosteroid-free clinical remission for at least 1 year with infliximab and azathioprine, and were followed up for at least 1 year thereafter. Cumulative relapse rates and the median time to relapse were estimated statistically. Factors at cessation were also evaluated for their association with clinical relapse. After a median follow-up period of 4.3 years [range, 1-7.5 years], 60.3% [38/63] of patients had experienced clinical relapse. According to Kaplan-Meier survival analysis, the estimated cumulative relapse rates at 1, 4, and 6 years were 19.0%, 62.2%, and 75.2%, respectively, and the median relapse time was 3.3 years from infliximab cessation. According to multivariate Cox proportional hazard regression analysis, infliximab trough levels of ≥2.5 μg/mL and incomplete mucosal healing were associated with clinical relapse (hazard rati...Continue Reading

References

Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
May 15, 2007·Lancet·Daniel C Baumgart, William J Sandborn
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Jun 16, 2011·Inflammatory Bowel Diseases·Kofi Clarke, Miguel Regueiro
Sep 29, 2011·Gastroenterology·Edouard LouisUNKNOWN Groupe D'etudes Thérapeutiques Des Affections Inflammatoires Digestives
May 9, 2012·Gastroenterology·Jeffrey S HyamsAndreas Lazar
Nov 28, 2012·Alimentary Pharmacology & Therapeutics·T MolnárT Wittmann
May 15, 2013·Journal of Crohn's & Colitis·Valerie PittetUNKNOWN EPACT-II Update Panellists
Sep 17, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Guillaume BouguenWilliam J Sandborn
Feb 28, 2014·Inflammatory Bowel Diseases·Dario SorrentinoJosep Bassaganya-Riera
Jun 10, 2014·Journal of Crohn's & Colitis·F M RuemmeleUNKNOWN European Society of Pediatric Gastroenterology, Hepatology and Nutrition
Sep 10, 2014·Current Drug Targets·Silvio DaneseLaureal Peyrin-Biroulet
Dec 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Konstantinos PapamichaelMarc Ferrante
May 7, 2015·World Journal of Gastroenterology : WJG·Konstantinos Papamichael, Severine Vermeire
Jun 3, 2015·Alimentary Pharmacology & Therapeutics·S Ben-HorinX Roblin
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bella UngarShomron Ben-Horin
Mar 24, 2016·The American Journal of Gastroenterology·Javier P GisbertMaría Chaparro

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Citations

Oct 17, 2019·HLA : Immune Response Genetics·Ben M MaternMarcel G J Tilanus
May 16, 2020·Current Opinion in Rheumatology·Konstantinos Papamichael, Adam S Cheifetz
Mar 7, 2020·Journal of Pediatric Gastroenterology and Nutrition·Isabel Pinto PaisJorge Amil Dias
Apr 10, 2021·Inflammatory Bowel Diseases·Jeremy AdlerAndrew A M Singer

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