Subthreshold membrane responses underlying sparse spiking to natural vocal signals in auditory cortex

The European Journal of Neuroscience
Krista E Perks, Timothy Q Gentner

Abstract

Natural acoustic communication signals, such as speech, are typically high-dimensional with a wide range of co-varying spectro-temporal features at multiple timescales. The synaptic and network mechanisms for encoding these complex signals are largely unknown. We are investigating these mechanisms in high-level sensory regions of the songbird auditory forebrain, where single neurons show sparse, object-selective spiking responses to conspecific songs. Using whole-cell in vivo patch clamp techniques in the caudal mesopallium and the caudal nidopallium of starlings, we examine song-driven subthreshold and spiking activity. We find that both the subthreshold and the spiking activity are reliable (i.e. the same song drives a similar response each time it is presented) and specific (i.e. responses to different songs are distinct). Surprisingly, however, the reliability and specificity of the subthreshold response was uniformly high regardless of when the cell spiked, even for song stimuli that drove no spikes. We conclude that despite a selective and sparse spiking response, high-level auditory cortical neurons are under continuous, non-selective, stimulus-specific synaptic control. To investigate the role of local network inhibitio...Continue Reading

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Feb 13, 2016·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Satoko OnoYoshimasa Seki
Jan 29, 2019·PLoS Computational Biology·Margot C Bjoring, C Daniel Meliza
Dec 8, 2017·Journal of Neurophysiology·Andrew N Chen, C Daniel Meliza

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