Subtle cognitive impairment as a marker of Alzheimer's pathologies and clinical progression in cognitively normal individuals.

Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Xue-Ning ShenAlzheimer's Disease Neuroimaging Initiative

Abstract

Subtle cognitive impairment (SCI) may appear before pathological changes surpass thresholds for abnormality. We aimed to investigate whether SCI could predict Alzheimer's pathologies and advancement. A total of 816 cognitively normal individuals were enrolled to assess the longitudinal neuropathological and clinical correlates of baseline SCI, via linear mixed-effects and Cox proportional-hazard models. Cross-lagged panel models were used in specific time waves. SCI individuals had a faster increase in brain amyloid burden and a higher risk of conversion. They also showed greater rates of cerebrospinal fluid (CSF) phosphorylated tau (p-tau)181 increase and glucose metabolism decrease. In addition, baseline SCI predicted worse clinical progression, whereas multi-domain SCI advanced faster compared to the single domain group. Baseline SCI could be an imperative prediction indicator of clinical and pathological progression. It enables cognitive measures to be informative at a very early stage and provided objective criteria for high-risk population screening.

References

Mar 1, 1990·Psychological Bulletin·P M Bentler
Aug 8, 2009·Neurobiology of Aging·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Jul 2, 2010·Neurology·S M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 13, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicola ColeyBruno Vellas
Aug 4, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Monique M WilliamsJohn C Morris
Sep 10, 2013·Lancet Neurology·Stephanie Jb VosAnne M Fagan
Feb 22, 2014·Dementia and Geriatric Cognitive Disorders·Rebecca L KoscikMark A Sager
Dec 30, 2014·Brain : a Journal of Neurology·Niklas MattssonUNKNOWN Alzheimer's Disease Neuroimaging Initiative*
Mar 17, 2015·JAMA Neurology·Niklas MattssonUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 31, 2015·Psychological Methods·Ellen L HamakerRaoul P P P Grasman
Apr 5, 2015·Trends in Pharmacological Sciences·Kaj BlennowHenrik Zetterberg
Jun 19, 2015·Neurology·Jon B ToledoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 12, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tobias BittnerKaj Blennow
Feb 8, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Rachel F BuckleyUNKNOWN AIBL study
May 14, 2016·Science Translational Medicine·Matthew R BrierBeau M Ances
Jul 31, 2016·Neurology·Jasmeer P ChhatwalKeith A Johnson
Mar 3, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Oskar HanssonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors
Oct 17, 2018·JAMA : the Journal of the American Medical Association·Rik OssenkoppeleOskar Hansson
Jul 28, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saffire H KranceUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 2, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Erin M JonaitisSterling C Johnson
Nov 25, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kathryn V PappUNKNOWN Collaborators from the Harvard Aging Brain Study, the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging
Feb 19, 2020·Biological Psychiatry·Jeremy A ElmanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 13, 2020·Nature Medicine·Nicolas R BarthélemyUNKNOWN Dominantly Inherited Alzheimer Network
Apr 15, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Daniel E GustavsonWilliam S Kremen

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