Subtle genomic alterations and genomic instability revealed in diploid cancer cell lines.

Cancer Letters
Xueying MaoYong-Jie Lu

Abstract

To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable lines CAL51 and SK-UT-1B. The number of de novo, non-clonal chromosome rearrangements was also significantly higher in CH1 than CAL51 and SK-UT-1B (p=0.001). This study reveals multiple genomic abnormalities in tumors with near normal karyotypes and suggests that genomic instability may be essential in cancer development.

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Apr 14, 2007·Genes, Chromosomes & Cancer·Xueying MaoYong-Jie Lu

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Citations

Feb 24, 2010·Prostate Cancer and Prostatic Diseases·L ShanUNKNOWN Transatlantic Prostate Group
Feb 1, 2014·Cell Death & Disease·E PantaziM P Philpott
May 1, 2009·Expert Opinion on Medical Diagnostics·Lara K BoydYong-Jie Lu

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