Subtle ultrasonographic anomalies: do they improve the Down syndrome detection rate?

American Journal of Obstetrics and Gynecology
O DerenR O Bahado-Singh

Abstract

Our purpose was to determine whether the identification of subtle anomalies further improves Down syndrome detection over standard ultrasonographic biometry and the detection of gross morphologic defects. The screening efficiency of clinodactyly, dilated renal pelvis (> or =4 mm), echogenic bowel, mild ventriculomegaly (> or =10 to 15 mm), and two-vessel cord was determined prospectively in midtrimester fetuses at amniocentesis. The screening efficiency of increased nuchal thickness and shortened long-bone length (standard biometry) and gross morphologic defects was determined for comparison. Multiple backward stepwise regression analysis was used to determine which subtle anomalies significantly correlated with Down syndrome detection rate and whether they increased Down syndrome detection over that with standard biometry and morphologic defects. Although all subtle anomalies except two-vessel cord correlated with the presence of Down syndrome on univariate analysis, only echogenic bowel (Wald chi2 = 15.0211, p = 0.0001) and clinodactyly (Wald chi2 = 9.4273, p = 0.002) persisted in regression analysis of the subtle anomaly group. When either of the above-described anomalies was present, the detection rate for Down syndrome was...Continue Reading

References

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Citations

Nov 24, 2007·Fetal Diagnosis and Therapy·Csaba PappZoltán Papp
Dec 5, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M AgathokleousK H Nicolaides
May 29, 2003·Seminars in Perinatology·David A Nyberg, Vivienne L Souter
May 29, 2003·Seminars in Perinatology·Ray Bahado-SinghMaurice J Mahoney
Aug 14, 2001·Clinics in Perinatology·M H GraupeL Platt
Jun 16, 2001·American Journal of Obstetrics and Gynecology·W J Ott, K Taysi
Nov 20, 2002·American Journal of Obstetrics and Gynecology·Ray O Bahado-SinghMaurice J Mahoney
Mar 25, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Chanchal Singh, Arijit Biswas
Jul 15, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y TannirandornS Phaosavasdi
Apr 6, 2004·Obstetrics and Gynecology Clinics of North America·Theresa L Stewart
Dec 11, 1999·Prenatal Diagnosis·A FarinaL Bovicelli
Nov 5, 2003·Clinical Obstetrics and Gynecology·James F X Egan
Dec 16, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G R DeVore
Apr 15, 2000·American Journal of Medical Genetics·A FarinaD W Bianchi
Jun 10, 2000·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R O Bahado-SinghM J Mahoney
May 20, 2000·The Journal of Perinatal & Neonatal Nursing·C Kubas
Mar 14, 2007·Current Opinion in Obstetrics & Gynecology·Fionnuala M Breathnach, Fergal D Malone
Dec 22, 2006·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Zsanett SzigetiCsaba Papp
Feb 2, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Adolfo EtchegarayLaura Igarzabal
Feb 17, 2007·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Fionnuala M BreathnachFergal D Malone
Aug 31, 2006·Journal de gynécologie, obstétrique et biologie de la reproduction·G GrangéD Cabrol

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