Subtleties in practical application of prolonged infusion of β-lactam antibiotics

International Journal of Antimicrobial Agents
Jan J De WaeleJason A Roberts

Abstract

Prolonged infusion (PI) of β-lactam antibiotics is increasingly used in order to optimise antibiotic exposure in critically ill patients. Physicians are often not aware of a number of subtleties that may jeopardise the treatment. In this clinically based paper, we stress pragmatic issues, such as the importance of a loading dose before PI, and discuss a number of important practicalities that are mandatory to benefit from the pharmacokinetic advantages of prolonged β-lactam antibiotic administration.

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Feb 25, 2009·Critical Care Medicine·Jason A Roberts, Jeffrey Lipman
Apr 23, 2009·Critical Care Medicine·Jason A RobertsJeffrey Lipman
Sep 9, 2010·Antimicrobial Agents and Chemotherapy·Barbara ClausDirk Vogelaers
Mar 16, 2011·Antimicrobial Agents and Chemotherapy·Jason A RobertsJeffrey Lipman
Aug 18, 2012·Annals of Intensive Care·Mohd H Abdul-AzizJason A Roberts
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 16, 2013·International Journal of Antimicrobial Agents·J J De WaeleE Hoste
Sep 3, 2013·International Journal of Antimicrobial Agents·Giuseppe Stefano CasuFabio Silvio Taccone
Dec 24, 2013·International Journal of Antimicrobial Agents·Shawn H MacVaneDavid P Nicolau
Mar 25, 2014·International Journal of Antimicrobial Agents·Jocelyn TeoAndrea Lay-Hoon Kwa
Jun 3, 2015·Journal of Chemotherapy·Mieke CarlierVeronique Stove

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Citations

Jul 15, 2016·Clinical Microbiology Reviews·Mordechai GrupperDavid P Nicolau
Sep 10, 2015·Antimicrobial Agents and Chemotherapy·Pieter A J G De CockPeter De Paepe
Oct 10, 2018·Current Opinion in Infectious Diseases·Aaron J HeffernanJason A Roberts
Jan 20, 2019·Intensive Care Medicine·Jean-François TimsitFrançois Barbier
Feb 13, 2020·Intensive Care Medicine·Jean-François TimsitMatteo Bassetti
Jun 23, 2020·Expert Review of Anti-infective Therapy·Petros I Rafailidis, Matthew E Falagas
Feb 12, 2021·Antibiotics·Stephen LittleHelen Billman-Jacobe

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