PMID: 8957548Jan 1, 1996Paper

Subtype 2 and atypical angiotensin receptors in the human heart

Basic Research in Cardiology
V Regitz-ZagrosekE Fleck

Abstract

Angiotensin receptors have been described in the human heart and are suspected to play a central role in remodeling after myocardial infarction and in cardiac hypertrophy. Two subtypes, AT1 and AT2, have so far been described in humans, with AT2 being the dominant subtype in human atria. We have now determined subtype numbers and distribution by binding in ventricular myocardium from patients with end-stage heart failure. We found about 50-80% of subtype AT2 in the right and left ventricles from patients with end-stage heart failure due to coronary artery disease and cardiomyopathy, indicating that AT2 is the dominant angiotensin receptor subtype in the whole human heart. To determine the cellular localization of angiotensin receptors in human myocardium in addition to the known localization on myocytes, smooth muscle cells and endothelial cells, we investigated cardiac fibroblasts. They express an angiotensin receptor with yet incompletely understood binding characteristics which is coupled to proliferation and DNA synthesis. As AT2 is the dominant angiotensin receptor subtype in human heart, we cloned the complete mRNA sequence by a rapid amplification of cDNA ends (RACE) procedure and thereafter the promoter sequence from a ...Continue Reading

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Citations

Mar 27, 2001·British Journal of Pharmacology·C M FilipeanuA Nelemans
May 19, 2007·Trends in Endocrinology and Metabolism : TEM·Rajesh KumarKenneth M Baker
Apr 21, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M T R Lima-LandmanA J Lapa
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Aug 9, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Jose L Labandeira-GarciaAna I Rodríguez-Perez
Jul 30, 2014·Frontiers in Neuroanatomy·Jose L Labandeira-GarcíaAna I Rodríguez-Perez
Jan 22, 2019·Journal of Alzheimer's Disease : JAD·John W Wright, Joseph W Harding

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