1. Presynaptic alpha 2-adrenoceptors in a few tissues have recently been pharmacologically classified in functional studies. 2. Autoreceptors are of alpha 2A-subtype in rabbit occipito-parietal cortex, rat cerebral cortex, vas deferens, submandibular gland, kidney, guinea-pig ileum submucosal arterioles and urethra. 3. Heteroreceptors are of alpha 2A-subtype in rat cerebral cortex, vas deferens, guinea-pig ileum submucosal plexus and Auerbach's plexus. 4. In rat atria autoreceptors have been shown to be of alpha 2B-subtype. 5. Classification is done mainly with alpha 2A-adrenoceptor-selective oxymetazoline, WB 4101 and BRL 44408, and the alpha 2B-adrenoceptor-selective prazosin, AR-C 239, chlorpromazine and BRL 41992. 6. With four alpha 2-adrenoceptor subtypes to consider, a larger number of subtype-selective compounds may have to be characterized in the classification in the many tissues, where presynaptic alpha 2-adrenoceptors are found.
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta
Subtype classification of the presynaptic alpha-adrenoceptors which regulate [3H]-noradrenaline secretion in guinea-pig isolated urethra.
Investigations of prejunctional alpha 2-adrenoceptors in rat atrium, vas deferens and submandibular gland
Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships.
Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
Functional evidence that acetylcholine release from Auerbach's plexus of guinea-pig ileum is modulated by alpha 2A-adrenoceptor subtype.
The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype.
Functional characterization of neuronal pre and postsynaptic alpha 2-adrenoceptor subtypes in guinea-pig submucosal plexus.
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2
Basic mechanisms and local modulation of nerve impulse-induced secretion of neurotransmitters from individual sympathetic nerve varicosities.
Estimation of pA2 values at presynaptic alpha 2-autoreceptors in rabbit and rat brain cortex in the absence of autoinhibition
Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes
The pharmacology of alpha 1- and alpha 2-adrenoceptors: evidence for and against a further subdivision
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor
Studies of alpha 2-adrenoceptor antagonist potency in vitro: comparisons in tissues from rats, rabbits, dogs and humans
Facilitation, and muscarinic and alpha-adrenergic inhibition of the secretion of 3H-acetylcholine and 3H-noradrenaline from guinea-pig ileum myenteric nerve terminals
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists
Site(s) and ionic basis of alpha-autoinhibition and facilitation of "3H'noradrenaline secretion in guinea-pig vas deferens
3H]Rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: possible heterogeneity of alpha 2-adrenoceptors
Alpha 2 adrenergic receptors are located prejunctionally in the Auerbach's plexus of the guinea pig small intestine: direct demonstration by radioligand binding
Dissociation of presynaptic alpha 2-adrenoceptors following prazosin administration: presynaptic effect of prazosin
Autoradiographic comparison of [3H]-clonidine binding to non-adrenergic sites and alpha(2)-adrenergic receptors in human brain
Effect of left ventricular pressure and volume overload on alpha-adrenoceptor activity in patients with rheumatic heart valvular disease
Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice
The effect of phenylpropanolamine on the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetized, conscious dog
Selectivity of oxymetazoline for urethral pressure vs blood pressure in the anaesthetized female rabbit
Enhanced functionalisation of major facilitator superfamily transporters via fusion of C-terminal protein domains is both extensive and varied in bacteria
Presynaptic alpha 2A-adrenoceptors regulate the 3H-noradrenaline secretion in the guinea-pig urethra
In vitro alpha-adrenoceptor autoradiography of the urethra and urinary bladder of the female pig, cat, guinea-pig and rat
The homotetramerization of a GPCR transmits the 20-hydroxyecdysone signal and increases its entry into cells for insect metamorphosis.
Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons
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