Subtype classification of presynaptic alpha 2-adrenoceptors

General Pharmacology
P Alberts

Abstract

1. Presynaptic alpha 2-adrenoceptors in a few tissues have recently been pharmacologically classified in functional studies. 2. Autoreceptors are of alpha 2A-subtype in rabbit occipito-parietal cortex, rat cerebral cortex, vas deferens, submandibular gland, kidney, guinea-pig ileum submucosal arterioles and urethra. 3. Heteroreceptors are of alpha 2A-subtype in rat cerebral cortex, vas deferens, guinea-pig ileum submucosal plexus and Auerbach's plexus. 4. In rat atria autoreceptors have been shown to be of alpha 2B-subtype. 5. Classification is done mainly with alpha 2A-adrenoceptor-selective oxymetazoline, WB 4101 and BRL 44408, and the alpha 2B-adrenoceptor-selective prazosin, AR-C 239, chlorpromazine and BRL 41992. 6. With four alpha 2-adrenoceptor subtypes to consider, a larger number of subtype-selective compounds may have to be characterized in the classification in the many tissues, where presynaptic alpha 2-adrenoceptors are found.

References

Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Jan 1, 1979·Progress in Neurobiology·E S Vizi
Nov 1, 1991·British Journal of Pharmacology·S Uhlén, J E Wikberg
May 1, 1991·British Journal of Pharmacology·N LimbergerK Starke
Oct 1, 1990·British Journal of Pharmacology·S Connaughton, J R Docherty
Feb 1, 1991·Trends in Pharmacological Sciences·J K HarrisonK R Lynch
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J W LomasneyR J Lefkowitz
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
Sep 8, 1989·Science·L J EmorineA D Strosberg
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W ReganB K Kobilka
Jan 1, 1985·Clinical Science·G M Drew
May 1, 1985·Pharmacology, Biochemistry, and Behavior·D B Bylund
Mar 1, 1987·Biopharmaceutics & Drug Disposition·L G MillerR I Shader
Jun 1, 1973·European Journal of Pharmacology·B Delbarre, H Schmitt
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Dec 1, 1982·Journal of Medicinal Chemistry·P B Timmermans, P A van Zwieten
Nov 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J E PiletzA Halaris
Mar 1, 1959·British Journal of Pharmacology and Chemotherapy·O ARUNLAKSHANA, H O SCHILD
Jun 1, 1948·The American Journal of Physiology·R P AHLQUIST

❮ Previous
Next ❯

Citations

May 20, 1998·Journal of Molecular Neuroscience : MN·D ParnasM Linial
Jun 4, 1999·European Journal of Pharmacology·P AlbertsM G Fredrickson
Aug 29, 2000·Scandinavian Journal of Urology and Nephrology·A R ModiriP Alberts
Sep 19, 2001·American Journal of Veterinary Research·G ReC Girardi
Jan 21, 2012·ChemMedChem·Eric JnoffCéline Vermeiren
Nov 30, 2000·Scandinavian Journal of Urology and Nephrology·M C MonneronP Alberts
Oct 20, 2005·Clinical Science·Nancy L Kanagy
Jun 1, 1997·Trends in Pharmacological Sciences·E MacDonaldM Scheinin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here