Subtype-selective nicotinic acetylcholine receptor agonists can improve cognitive flexibility in an attentional set shifting task

Neuropharmacology
Christopher WoodMohammed Shoaib

Abstract

Nicotinic acetylcholine receptors (nAChRs) are considered to be viable targets to enhance cognition in patients diagnosed with schizophrenia. Activation of nAChRs with selective nicotinic receptor agonists may provide effective means to pharmacologically treat cognitive deficits observed in schizophrenia. Cognitive flexibility is one aspect of cognition, which can be assessed in a rodent model of the attentional set-shifting task (ASST). The aim of the present study was two-fold, firstly, to evaluate the efficacy of a series of subtype selective nAChR agonists, such as those that target α7 and α4β2 nAChR subtypes in non-compromised rodents. Secondly, nicotine as a prototypic agonist was evaluated for its effects to restore attentional deficits produced by sub-chronic ketamine exposure in the ASST. Male hooded Lister rats underwent habituation, consisting of a simple odour and medium discrimination with subsequent assessment 24 h later. In experimentally naïve rats, α7 subtype selective agonists, compound-A and SSR180711 along with PNU-120596, an α7 positive allosteric modulator (PAM), were compared against the β2* selective agonist, 5IA-85380. All compounds except for PNU-120596 were observed to significantly improve extra-dime...Continue Reading

References

Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R FreedmanW Byerley
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D Jentsch, R H Roth
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vincenzo De LucaJames L Kennedy
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Jeffrey W DalleyTrevor W Robbins
Dec 8, 2004·Journal of Psychopharmacology·Kristi A SaccoTony P George
Jan 15, 2005·Progress in Neurobiology·C Gotti, F Clementi
Mar 25, 2005·The European Journal of Neuroscience·Joshua S RodeferMark G Baxter
May 5, 2005·Drug and Alcohol Dependence·Jennifer W TideyRobert M Swift
Aug 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philippe PichatBernard Scatton
Oct 5, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruno BitonBernard Scatton
Apr 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ruth S BarrA Eden Evins
Sep 22, 2007·Schizophrenia Research·Christopher G AhnAllenMargaret A Niznikiewicz
Dec 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joshua S RodeferJørn Arnt
Dec 25, 2008·Psychological Medicine·J McKirdyA M McIntosh
Dec 27, 2008·Behavioural Brain Research·Stan B FlorescoTakeshi Enomoto
Feb 18, 2009·The Australian and New Zealand Journal of Psychiatry·Simon ChapmanKevin McGeechan
Aug 15, 2009·Journal of Molecular Neuroscience : MN·Sharon MexalSherry Leonard
Sep 5, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Agnieszka NikiforukPiotr Popik
Jun 18, 2011·Genes, Brain, and Behavior·J W YoungM A Geyer
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samantha L RushforthMohammed Shoaib
Jul 11, 2012·Neuropharmacology·Claire Allison, Mohammed Shoaib
Oct 11, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Laetitia FelliniJohn Talpos

❮ Previous
Next ❯

Citations

Aug 24, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Alvin V Terry, Patrick M Callahan
Jun 13, 2018·Pharmacological Reports : PR·Agnieszka Nikiforuk
Mar 7, 2020·Journal of Psychopharmacology·Stefan AhrensChristiane M Thiel
Feb 25, 2017·Frontiers in Pharmacology·Higor A IhaYukihiro Ohno
Dec 22, 2020·ACS Pharmacology & Translational Science·Cassandra J HatzipantelisChristopher J Langmead

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.