Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors

Bioorganic & Medicinal Chemistry Letters
Markus A AltmeyerChristian D Klein

Abstract

Inhibitors of methionine aminopeptidases (MetAPs) are treatment options for various pathological conditions. Several inhibitor classes have been described previously, but only few data on the subtype selectivity, which is of crucial importance for these enzymes, is available. We present a systematic study on the subtype- and species-selectivity of MetAP inhibitors that require the binding of an auxiliary metal ion. This includes, in particular, compounds based on the benzimidazole pharmacophore, but also hydroxyquinoline and picolinic acid derivatives. Our data indicates that a significant degree of selectivity can be attained with metal-dependent MetAP inhibitors.

References

Mar 10, 2000·Biochimica Et Biophysica Acta·W T Lowther, B W Matthews
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kruger, W D Figg

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Citations

Jul 14, 2011·Analytical and Bioanalytical Chemistry·Sayaka ShibataErkang Fan
Apr 1, 2015·Future Medicinal Chemistry·Luca Costantino, Daniela Barlocco
Mar 28, 2017·SLAS Discovery·Svenja LeyHeinz Ruffner
Feb 9, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kengo HanayaShin Aoki
Apr 4, 2018·Current Medicinal Chemistry·Raivis Zalubovskis, Jean-Yves Winum
Jan 17, 2017·Bioorganic & Medicinal Chemistry·Travis R HelgrenTimothy J Hagen
Mar 20, 2018·Bioorganic & Medicinal Chemistry Letters·Travis R HelgrenTimothy J Hagen
Aug 26, 2014·Journal of Medicinal Chemistry·Christian JöstChristian D Klein
Sep 8, 2018·Chemical Reviews·Allie Y ChenSeth M Cohen

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