Abstract
Concomitant neurologic manifestations and positive antiphospholipid antibodies (APAs) have been investigated in different manners. The present study aimed to investigate the association between neurologic manifestations and APAs. This cross-sectional descriptive study was conducted on 100 consecutive patients with selected neurological manifestations and at least one positive APAs within the age range of 20-50 years, referred to the Rheumatic Diseases Research Center from the Northeast Central Neurology Department of Iran during August 2012 to March 2014. According to the results, 89% of the participants were persistently positive for APAs, including lupus anticoagulant, IgG anticardiolipin (aCL), IgM aCL, IgG β-2 glycoprotein 1 (β2- GP1), and IgM β2-GP1, observed in 16%, 41%, 42%, 17%, and 15% of the patients, respectively. Furthermore, 10% of the patients had concomitant lupus manifestations, and 37% of them showed anti-DNA. The IgG and IgM aCL were the most prevalent antibodies. Cerebral vascular accident (33%), retinal artery/vein occlusion (21%), and seizure (20%) were the most frequent presentations among the patients. In addition, the patients with multiple sclerosis (composing 3% of the subjects) were 100% positive for ...Continue Reading
References
Mar 1, 1982·Archives of Neurology·B L Agrawal, R P Foa
May 1, 1995·The Journal of Pediatrics·Y UzielE D Silverman
Apr 1, 1994·Arthritis and Rheumatism·M T HerranzG R Hughes
Oct 1, 1996·Stroke; a Journal of Cerebral Circulation·M A DeschiensM G Bousser
Jul 1, 1997·The American Journal of Medicine·D VerrotP J Weiller
Jun 1, 1997·American Journal of Ophthalmology·B WiechensR Rochels
Apr 7, 1999·Lupus·J ChapmanA D Korczyn
Sep 2, 2000·Journal of Autoimmunity·R L Brey
Jul 21, 2001·Epilepsy Research·K ErikssonM Koivikko
Jul 27, 2001·Current Rheumatology Reports·D Tanne, S Hassin-Baer
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
Aug 3, 2002·Rheumatology·D ErkanM D Lockshin
Feb 22, 2003·Rheumatology·G SannaG R V Hughes
May 19, 2004·Clinical and Experimental Immunology·C G Mackworth-Young
Mar 22, 2005·Annals of the Rheumatic Diseases·I KrauseY Shoenfeld
Apr 12, 2005·Pediatric Clinics of North America·Angelo Ravelli, Alberto Martini
Jan 18, 2006·Clinical Neurology and Neurosurgery·Wolfgang MiesbachInge Scharrer
Jul 15, 2009·Seminars in Arthritis and Rheumatism·Yoav ArnsonHoward Amital
Dec 10, 2013·Hematology·Wendy Lim