Subtypes of depression characterized by different cognitive decline and brain activity alterations.

Journal of Psychiatric Research
Xiao YangXiaohong Ma

Abstract

Depression is characterized by the heterogeneity in anti-depressant treatment response and clinical outcomes. Cognitive impairment may be one of the more practically important aspects of depression. A new approach was to identify neuropsychologically derived depression subtypes based on the trajectory of neuro-cognition such as intelligence quotient (IQ) change. We used a classical premorbid IQ prediction algorithm and then compared predicted premorbid IQ with current IQ. IQ change was used to delineate the patterns of neuropsychological heterogeneity within a large dataset consisting of 131 patients with major depressive disorder (MDD) and 165 healthy controls (HCs). Neurocognitive results from CANTAB and 3 T resting-state fMRI data were compared among the subgroups identified. IQ change heterogeneity identified two subgroups within the MDD group: preserved IQ (PIQ) and deteriorated IQ (DIQ) in MDD. The DIQ subgroup was marked by poorer functioning across multiple cognition domains, including increased impairments in motor speed, cognitive flexibility, and catastrophic thinking when compared to PIQ and HCs. Moreover, cognitive performance of patients with DIQ was correlated with IQ decline. Also, increased brain activity of an...Continue Reading

References

Nov 14, 1997·Journal of Clinical Psychology·A M PaoloW C Koller
Jun 27, 2000·Schizophrenia Research·J Addington, D Addington
Sep 15, 2000·Archives of General Psychiatry·T W WeickertD R Weinberger
Apr 11, 2001·Seminars in Clinical Neuropsychiatry·A L BrodyS Saxena
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Aug 3, 2002·The American Journal of Psychiatry·James M GoldAnthony F Lehman
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christian F BeckmannStephen M Smith
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Eileen M JoyceThomas R E Barnes
Oct 26, 2006·Neurotoxicity Research·K EbmeierD Steele
Jun 29, 2007·Human Brain Mapping·Paul B FitzgeraldZafiris J Daskalakis
Apr 17, 2008·The American Journal of Psychiatry·Kristen A WoodberryLarry J Seidman
Mar 25, 2009·Social Cognitive and Affective Neuroscience·Cédric LemognePhilippe Fossati
Jul 22, 2009·Social Cognitive and Affective Neuroscience·Marcia K JohnsonYael Levin
Jun 12, 2013·Frontiers in Human Neuroscience·Danilo BzdokSimon B Eickhoff
Aug 9, 2013·JAMA Psychiatry·René S Kahn, Richard S E Keefe
Aug 19, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P GorwoodM L Cléry-Melun
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Apr 1, 2006·Acta Neuropsychiatrica·Morgan Haldane, Sophia Frangou
Mar 30, 2017·Frontiers in Neuroscience·Lisa D NickersonChristian F Beckmann
Aug 4, 2018·Nature Communications·Jing SuiVince D Calhoun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.