Subtypes of functional alpha1- and alpha2-adrenoceptors

European Journal of Pharmacology
J R Docherty


In this review, subtypes of functional alpha1- and alpha2-adrenoceptors are discussed. These are cell membrane receptors, belonging to the seven transmembrane spanning G-protein-linked family of receptors, which respond to the physiological agonists noradrenaline and adrenaline. Alpha1-adrenoceptors can be divided into alpha1A-, alpha1B- and alpha1D-adrenoceptors, all of which mediate contractile responses involving Gq/11 and inositol phosphate turnover. A 4th alpha1-adrenoceptor, the alpha1L-, has been postulated to mediate contractions in some tissues, but its relationship to cloned receptors remains to be established. Alpha2-adrenoceptors can be divided into alpha2A-, alpha2B- and alpha2C-adrenoceptors, all of which mediate contractile responses. Prejunctional inhibitory alpha2-adrenoceptors are predominantly of the alpha2A-adrenoceptor subtype (the alpha2D-adrenoceptor is a species orthologue), although alpha2C-adrenoceptors may also occur prejunctionally. Although alpha2-adrenoceptors are linked to inhibition of adenylate cyclase, this may not be the primary signal in causing smooth muscle contraction; likewise, prejunctional inhibitory actions probably involve restriction of Ca2+ entry or opening of K+ channels. Receptor ...Continue Reading


Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Sep 1, 1977·Life Sciences·S Berthelsen, W A Pettinger
Oct 1, 1979·British Journal of Pharmacology·G M Drew, S B Whiting
Oct 1, 1977·Physiological Reviews·T C Westfall
May 27, 1976·Nature·M G ZieglerI J Kopin
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D B Bylund
Mar 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·S P RobertsM V Sennitt
Dec 1, 1992·British Journal of Pharmacology·M RaiteriA Ruelle
Apr 1, 1991·British Journal of Pharmacology·I AkersA T Sullivan
Jun 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·R BültmannK Starke
Jan 11, 1991·Pharmacology·M A OriowoR R Ruffolo
Jan 1, 1990·British Journal of Pharmacology·I MuramatsuM Oshita
Oct 1, 1990·British Journal of Pharmacology·S Connaughton, J R Docherty
Sep 21, 1990·European Journal of Pharmacology·M T PiascikK W Barron
Feb 1, 1991·Trends in Pharmacological Sciences·J K HarrisonK R Lynch
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·M Borton, J R Docherty
Mar 20, 1990·European Journal of Pharmacology·M Kaschube, H Brasch
Apr 1, 1987·Journal of Cardiovascular Pharmacology·L C Rump, H Majewski
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S CotecchiaB K Kobilka
Sep 1, 1988·Journal of Autonomic Pharmacology·J R Docherty
Jan 1, 1985·Clinical Science·G M Drew
Sep 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·I MusgraveH Majewski
Oct 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·R R RuffoloJ P Hieble
Jan 27, 1988·European Journal of Pharmacology·J R Docherty
Oct 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·S Connaughton, J R Docherty
May 1, 1985·Pharmacology, Biochemistry, and Behavior·D B Bylund
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·C AllgaierG Hertting
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Jul 1, 1974·Biochemical Pharmacology·S Z Langer

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