Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors.

Brain Research
Morris BenvenisteDavid D Mott

Abstract

Interactions between cholinergic and glutamatergic neurotransmitter systems influence synaptic transmission and plasticity. While previous studies have examined cross-talk between acetylcholine (ACh) and NMDA or AMPA receptors, little is known about the effect of ACh on kainate receptors (KARs). We show that stimulation of m1 or m3 muscarinic ACh receptors (mAChRs) for 2min potentiates recombinant KAR currents in a long lasting fashion. Muscarinic AChR activation potentiates heteromeric GluK2/GluK4 and GluK2/GluK5 receptors, but not homomeric GluK2 receptors. In hippocampal slices kainate potentiates mossy fiber axon excitability. Transient mAChR activation enhances this action of kainate, suggesting a novel mechanism through which acetylcholine could modulate synaptic transmission in the hippocampus. KAR over-activation has been implicated in excitotoxic cell death. To establish the functional significance of the interaction between mAChRs and KARs we examined the effect of mAChR activation on KAR-mediated excitotoxicity. We find that during pharmacological blockade of NMDA and AMPA receptors, KAR activation with AMPA produces significant cell death in primary cortical culture. Concanavalin A (Con A), which selectively blocks ...Continue Reading

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Citations

May 16, 2013·Clinical Neuropharmacology·Chi-Un Pae
Nov 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Janet L Fisher, David D Mott
Jul 27, 2010·Brain Research·Morris BenvenisteDavid D Mott
Jan 26, 2013·Molecular Pharmacology·Asheebo Rojas, Raymond Dingledine
Aug 14, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Sep 1, 2018·Pharmacological Reports : PR·Dasiel O Borroto-EscuelaKjell Fuxe
Nov 4, 2021·Cerebral Cortex·Adam GorlewiczChristophe Mulle

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