Subventricular zone neural progenitors reverse TNF-alpha effects in cortical neurons

Stem Cell Research & Therapy
Raffaella MoriniMichela Matteoli

Abstract

Tumor necrosis factor alpha (TNFα) plays a physiological role in controlling synaptic transmission and plasticity in the healthy central nervous system by modulating glutamate receptor trafficking to the plasma membrane. TNFα expression is also rapidly induced in response to tissue injury and infection. By promoting the insertion of Ca(2+) permeable-AMPA receptors into the neuronal plasma membrane, this cytokine may cause excessive Ca(2+) influx into neurons, thus enhancing neuronal death. Primary cultures of cortical neurons were obtained from E18 foetal mice and incubated for 24 h with adult neural stem cells (aNPCs) either stimulated with lipopolysaccharide (LPS(+)aNPCs) or not (aNPCs). Cultures were treated with TNFα (100 ng/ml), and electrophysiological recordings were performed in different conditions to evaluate the effect of the cytokine on neuronal transmission. In this study, we demonstrate that aNPCs from the subventricular zone reverse the effects induced by the cytokine. Moreover, we show that the effect of aNPCs on cortical neurons is mediated by cannabinoid CB1 receptor activation. These data suggest that the role of aNPCs in preventing excitatory neurotransmission potentiation induced by TNFα on cortical neurons...Continue Reading

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Citations

Jan 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Huiling WangMohamad Taufik Hidayat Baharuldin
Jun 24, 2017·Brain Structure & Function·Patrizia PanzanelliJean-Marc Fritschy

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Methods Mentioned

BETA
fluorescence microscopy

Software Mentioned

pClamp
GraphPad
ImageJ
PRISM

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