Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA

Molecular Microbiology
Nicole TegtmeyerSteffen Backert

Abstract

Helicobacter pylori is a paradigm of persistent pathogens and major risk factor for developing severe diseases including adenocarcinoma in the human stomach. An important bacterial factor linked to gastric disease progression is the cag pathogenicity island-encoded type-IV secretion system (T4SS) effector protein CagA. Translocated CagA undergoes tyrosine phosphorylation at EPIYA-motifs and then activates or inactivates multiple host signaling proteins in a phosphorylation-dependent and phosphorylation-independent fashion. In this way, intracellular CagA acts as a 'masterkey' or 'picklock', which evolved during evolution to hijack key host cell signal transduction functions. Crucial targets of CagA represent a variety of serine/threonine and tyrosine kinases, which control major checkpoints of eukaryotic signaling. Here we review the signal transmission by translocated CagA on multiple receptor kinases (c-Met and EGFR) and non-receptor kinases (Src, Abl, Csk, aPKC, Par1, PI3K, Akt, FAK, GSK-3, JAK, PAK1, PAK2 and MAP kinases), manipulating a selection of fundamental processes in the human gastric epithelium such as cell adhesion, polarity, proliferation, motility, receptor endocytosis, cytoskeletal rearrangements, apoptosis, in...Continue Reading

References

Jan 15, 2002·The Journal of Biological Chemistry·Matthias SelbachSteffen Backert
Feb 2, 2002·Nature Reviews. Molecular Cell Biology·Catherine A Hazzalin, Louis C Mahadevan
Nov 7, 2002·Molecular Cell·Hitomi MimuroChihiro Sasakawa
Nov 26, 2002·The Journal of Biological Chemistry·Ryouhei TsutsumiMasanori Hatakeyama
Apr 30, 2003·The Journal of Cell Biology·Yuri ChurinMichael Naumann
Jun 26, 2003·Molecular Microbiology·Manfred RohdeRainer Haas
Feb 14, 2004·The Journal of Biological Chemistry·Hideaki HigashiMasanori Hatakeyama
Sep 21, 2004·Proteomics·Matthias SelbachThomas F Meyer
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Jun 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sabine BrandtSteffen Backert
Jul 20, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aime T FrancoRichard M Peek
Dec 16, 2005·Molecular and Cellular Biology·Ryouhei TsutsumiMasanori Hatakeyama
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Bruce T SeetTony Pawson
Sep 1, 2006·The Journal of Biological Chemistry·Barbara Tanos, Ann Marie Pendergast
Sep 7, 2006·The Journal of Biological Chemistry·Shumei RenMasanori Hatakeyama
Sep 23, 2006·The Journal of Biological Chemistry·Maria J OliveiraCeu Figueiredo
Apr 5, 2007·Annals of the New York Academy of Sciences·Hye Yeon BaekHyeyoung Kim
Aug 29, 2007·The Journal of Pathology·C B JacksonA S Giraud
Jan 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Naomi OhnishiMasanori Hatakeyama
Jan 18, 2008·Cancer Research·Aime T FrancoRichard M Peek
Oct 29, 2008·Oncogene·T F Franke
Nov 20, 2008·Cellular Microbiology·Bianca BauerThomas F Meyer

❮ Previous
Next ❯

Citations

Oct 13, 2017·Toxins·Mark S McClainTimothy L Cover
Dec 1, 2017·PloS One·Kennady K BullockTimothy L Cover
Dec 5, 2018·Infection and Immunity·John T LohTimothy L Cover
Feb 20, 2019·Critical Reviews in Microbiology·Dan ZouYe Zhang
May 3, 2019·Journal of Gastroenterology·Shamshul AnsariYoshio Yamaoka
Oct 24, 2019·Annals of the New York Academy of Sciences·Apostolis PapaefthymiouJannis Kountouras
May 1, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Asif SukriNik Ritza Kosai
Jan 17, 2019·Journal of Clinical Medicine·Yi-Hsing ChenChih-Ho Lai
Aug 6, 2020·Frontiers in Microbiology·Wolfgang FischerSteffen Backert
Dec 14, 2017·Molecular Microbiology·Elisabeth GrohmannSteffen Backert
Sep 1, 2020·Pathogens and Disease·Bianca E ChichirauSilja Wessler
May 27, 2020·Trends in Microbiology·Timothy L CoverMelanie D Ohi
Oct 15, 2020·International Journal of Molecular Sciences·Shamshul Ansari, Yoshio Yamaoka
Oct 15, 2020·Applied Microbiology and Biotechnology·Paula Roszczenko-JasińskaElżbieta K Jagusztyn-Krynicka
Jul 13, 2021·Molecular Microbiology·Timothy L Cover
Aug 11, 2021·Biochemical Society Transactions·Lok ManStuart J Cordwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

Bacterial Respiration

This feed focuses on cellular respiration in bacteria, known as bacterial respiration. Discover the latest research here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.