Success of intra-arterial chemotherapy (chemosurgery) for retinoblastoma: effect of orbitovascular anatomy

Archives of Ophthalmology
Brian P MarrDavid H Abramson

Abstract

To review results of orbital angiography performed during intra-arterial chemotherapy (chemosurgery) for treatment of retinoblastoma to assess the association of angiographic variability in orbitovascular anatomy with tumor response and outcomes. Medical records and 64 orbital angiograms were reviewed for 56 pediatric patients with retinoblastoma undergoing chemosurgery using a combination of melphalan hydrochloride, topotecan hydrochloride, or carboplatin. The major orbital arteries and capillary blush patterns were graded, and tumor response and recurrence were compared using the log-rank and Fisher exact tests. Statistically significant variables for tumor response were lacrimal artery prominence (P = .001), previous treatment (P = .003), and lacrimal blush (P = .004). The only statistically significant variable for vitreous seed response was ciliary body blush (P = .03). Statistically significant variables influencing time to recurrence and time to enucleation were choroidal blush absence (P = .01) and lacrimal artery presence (P = .03), respectively. The success of intra-arterial chemotherapy is dependent on delivery of drug to the target tumor within the eye via the ophthalmic artery. Because of the small volume of drug u...Continue Reading

Citations

Jan 16, 2014·Annual Review of Medicine·David H Abramson
Sep 21, 2013·Ophthalmic Surgery, Lasers & Imaging Retina·Yoshihiro YonekawaDeborah K Vanderveen
Nov 30, 2016·International Ophthalmology Clinics·Shuai YuanAnthony B Daniels
Apr 12, 2020·Journal of Neurointerventional Surgery·Ahmad SweidPascal Jabbour
Mar 1, 2013·Asia-Pacific Journal of Ophthalmology·Amy C Schefler, David H Abramson
Dec 7, 2016·International Journal of Oncology·Jiang-Ping WangBo Zhang
Sep 13, 2014·International Journal of Oncology·Katarzyna BrodowskaDemetrios G Vavvas
Sep 3, 2014·Journal of Neurointerventional Surgery·Todd A AbruzzoJames J Augsburger

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