Success of Maxillary Alveolar Defect Repair in Rats Using Osteoblast-Differentiated Human Deciduous Dental Pulp Stem Cells

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Arezoo JahanbinMohammad Ali Raisolsadat

Abstract

The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response in craniofacial abnormalities. The main aim of this study was to evaluate the regenerative potential of human dental pulp stem cells, isolated from deciduous teeth, for reconstructing maxillary alveolar defects in Wistar rats. Human deciduous dental pulp stem cells were isolated and stimulated to differentiate into osteoblasts in culture media. Maxillary alveolar defects were created in 60 Wistar rats by a surgical procedure. Then, on the basis of the type of graft used to repair the bone defect, the rats were divided into 6 equal groups: groups 1 and 2, transplantation of iliac bone graft; groups 3 and 4, transplantation of stem cells derived from deciduous dental pulp in addition to collagen matrix; groups 5 and 6, transplantation of just collagen matrix. Then, fetal bone formation, granulation tissue, fibrous tissue, and inflammatory tissue were evaluated by hematoxylin-eosin staining at 1 month (groups 1, 3, and 5) and 2 months (groups 2, 4, and 6) after surgery, and data were analyzed and compared using the Fisher exact test. Maximum fetal bone formation occurred in group 2, in which iliac bone graft was inse...Continue Reading

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Citations

Oct 1, 2019·The Journal of Craniofacial Surgery·Arezoo JahanbinMozhgan Kazemian
Jun 5, 2016·Current Opinion in Otolaryngology & Head and Neck Surgery·Raam S Lakhani
Jul 31, 2020·Tissue Engineering. Part a·Umadevi KandalamSteven I Kaltman
Sep 3, 2020·Tissue Engineering. Part B, Reviews·Jeremie D OliverRena N D'Souza
Jan 30, 2018·Journal of Tissue Engineering·Alessander Leyendecker JuniorDaniela Franco Bueno
Oct 21, 2020·Journal of Clinical Medicine·Jeremie D OliverMichael S Hu
Nov 28, 2020·Scientific Reports·Stephan Christian MöhlhenrichAli Modabber
Feb 26, 2020·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Elena María Castilla ParrillaRicardo Fernández Valadés
Mar 7, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Stephan Christian MöhlhenrichAli Modabber
Aug 23, 2021·Stem Cell Reviews and Reports·Xue-Cheng SunHong-Fei Xia
Oct 26, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·T PourlakM Yousefi

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