Success treatment of post-irradiation morphoea with acitretin and narrowband UVB

The Australasian Journal of Dermatology
Kate Newland, Gillian Marshman

Abstract

Post-irradiation morphoea is a rare but under-recognised complication of radiotherapy treatment for breast cancer. Management of this condition is difficult, and many cases are recalcitrant to therapy. A 43-year-old woman with breast cancer received radiotherapy following a mastectomy and partial axillary lymph node dissection, shortly after which she developed a hot, tender, erythematous and indurated plaque at the mastectomy site. Subsequently the skin became retracted, depressed and hyperpigmented. The clinical features, along with histological findings, were consistent with post-irradiation morphoea. Treatment with narrowband ultraviolet B and acitretin 10 mg daily was commenced 5 years following radiotherapy. After 2 months of therapy the patient reported significant improvement in tenderness and range of left arm movement. Objectively the plaque was less indurated and softer to palpation. We propose that this treatment regimen is an option in the management of post-irradiation morphoea.

References

Nov 1, 1991·The British Journal of Dermatology·R J van Dooren-GreebeR J Koopman
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J O ArchambeauT Wasserman
May 20, 1999·The Australasian Journal of Dermatology·N R BleaselV A Ahern
Feb 22, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·J V SchafferM Girardi
Jul 4, 2002·Annals of Surgical Oncology·Funda MericKelly K Hunt
Feb 21, 2006·Journal of the American Academy of Dermatology·Alexander KreuterThilo Gambichler
Mar 3, 2006·The Breast Journal·Steve DubnerBarbara Susnik
Jul 29, 2008·Human Pathology·Noreen WalshMichael Reardon
Aug 6, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WolffErnst Holler

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Citations

Nov 2, 2013·Indian Journal of Dermatology, Venereology and Leprology·Rashmi SarkarVijay K Garg
May 11, 2015·The American Journal of Case Reports·Koichi YanabaHidemi Nakagawa
Aug 16, 2016·Dermatology and Therapy·John Hassani, Steven R Feldman
Dec 25, 2016·Actas dermo-sifiliográficas·I Hernández AragüésR Suárez Fernández
Nov 8, 2017·Histopathology·Paula I Gonzalez-EricssonMelinda E Sanders
Sep 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M SpalekJ Gałecki
Jul 18, 2021·Pediatric Dermatology·Jacquelyn R Sink, Yvonne E Chiu

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