Successes & challenges in the atomistic modeling of light-harvesting and its photoregulation

Biochimica Et Biophysica Acta. Bioenergetics
Lorenzo CupelliniBenedetta Mennucci

Abstract

Light-harvesting is a crucial step of photosynthesis. Its mechanisms and related energetics have been revealed by a combination of experimental investigations and theoretical modeling. The success of theoretical modeling is largely due to the application of atomistic descriptions combining quantum chemistry, classical models and molecular dynamics techniques. Besides the important achievements obtained so far, a complete and quantitative understanding of how the many different light-harvesting complexes exploit their structural specificity is still missing. Moreover, many questions remain unanswered regarding the mechanisms through which light-harvesting is regulated in response to variable light conditions. Here we show that, in both fields, a major role will be played once more by atomistic descriptions, possibly generalized to tackle the numerous time and space scales on which the regulation takes place: going from the ultrafast electronic excitation of the multichromophoric aggregate, through the subsequent conformational changes in the embedding protein, up to the interaction between proteins.

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Citations

Jun 27, 2020·Physical Chemistry Chemical Physics : PCCP·Mattia BondanzaBenedetta Mennucci
Feb 2, 2020·Nature Communications·Lorenzo CupelliniBenedetta Mennucci
Jul 15, 2020·Physical Chemistry Chemical Physics : PCCP·Vladislav SlámaBenedetta Mennucci
Apr 17, 2020·Photosynthesis Research·Nicoletta LiguoriSebastian Thallmair
Sep 10, 2020·The Journal of Physical Chemistry. B·Lorenzo CupelliniJianshu Cao
Nov 20, 2020·Chemical Reviews·Julia Westermayr, Philipp Marquetand
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heiko LoksteinJan P Götze
Oct 22, 2019·The Journal of Physical Chemistry. B·Vangelis DaskalakisUlrich Kleinekathöfer
Sep 30, 2021·The Journal of Physical Chemistry Letters·Anthi ChrysafoudiVangelis Daskalakis

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