Successful chemotherapy with carboplatin and nab-paclitaxel for thymic large cell neuroendocrine carcinoma: A case report

Oncology Letters
Satoshi IgawaNoriyuki Masuda

Abstract

Thymic large cell neuroendocrine carcinomas (LCNECs) are rare, and the optimal regimen for second and subsequent lines of chemotherapy for the treatment of LCNECs remains unknown. In the present case study, a 59-year-old male with post-operative recurrent thymic LCNEC was treated with nab-paclitaxel and carboplatin every 4 weeks as third-line chemotherapy, and a partial response was achieved following 4 cycles of this regimen. The patient developed grade 4 neutropenia and grade 3 leukopenia, but none of the other toxicities, including peripheral neuropathy, were severe. Therefore, the patient was able to tolerate this salvage chemotherapy. To the best of our knowledge, the present study is the first case demonstrating clinically meaningful antitumor activity by combination chemotherapy with carboplatin and nab-paclitaxel, resulting in a positive response in a patient with thymic LCNEC.

References

Jun 1, 1977·The American Journal of Surgical Pathology·Y ShimosatoK Suemasu
Jan 1, 1991·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·I I Moisa, C E Silver
Feb 15, 1991·Cancer·S Suster, J Rosai
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J GroenE F Smit
Jul 19, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shigeo YamazakiNagahiro Saijo
Oct 18, 2005·Lancet·David M Jackman, Bruce E Johnson
Dec 15, 2005·Heart, Lung & Circulation·Liza Thomas, Norman Sadick
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neil DesaiPatrick Soon-Shiong
Oct 26, 2006·The Annals of Thoracic Surgery·Akira IyodaTakehiko Fujisawa
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sayaka OnodaUNKNOWN Thoracic Oncology Research Group Study 0301
Mar 5, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Motoki YanoYoshitaka Fujii
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
May 5, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Satoshi IgawaNobuyuki Yamamoto
Nov 26, 2010·Journal of Cardiothoracic Surgery·Fumihiro OgawaYukitoshi Satoh
Apr 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Girum L LemmaPatrick J Loehrer
Aug 16, 2011·The Breast : Official Journal of the European Society of Mastology·J Chirgwin, S L Chua
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Toshihiko AgatsumaKeishi Kubo
Feb 18, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Haruyasu MurakamiTomohide Tamura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.