Successful circumferential free tracheal transplantation in a large animal model

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Alejandro M BertolottiRoberto R Favaloro

Abstract

Long segment tracheobronchial stenoses are associated with high morbi-mortality rates and difficult treatment. Transplantation hasn't proved to be useful yet. Currently, the successful results achieved in small animal models couldn't be satisfactorily accomplished or extrapolated in large mammals. We aimed to evaluate the viability of orthotopic tracheal autoimplantation in an ovine model. All animals underwent tracheal transplantation of 4 cm (5-7 rings) of the cervical trachea and were divided randomly in two groups: isolated autoimplantation (Group A/6) and autoimplantation with omental wrapping (Group B/6). Clinical follow up and weekly bronchoscopical examinations were performed. The grafts were macroscopically, histologically, and bacteriologically analyzed. In group A, four animals achieved their planed survival and were sacrificed up to 60 days after transplantation with viable grafts. In group B, only two sheep had successful results. Graft failure with infection, necrosis and severe stenosis was observed in the rest of the animals from both groups. Pseudomonas aeruginose was isolated in all cases. The main complication of the omental pedicle was vascular congestion and peritracheal hemorrhage. Contrary to the data rep...Continue Reading

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Citations

Feb 18, 2015·Journal of Tissue Engineering and Regenerative Medicine·P LangeT Ansari
Mar 3, 2015·Analytical Biochemistry·Zhishui LiHeguang Huang
Nov 28, 2017·Current Stem Cell Reports·Elizabeth F MaughanPaolo De Coppi
May 1, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Victoria PepperTendy Chiang

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