Successful desensitization to cloxacillin in a patient with sepsis, with infective endocarditis and clinical suspicion of hypersensitivity to penicillins, a case report

Journal of Clinical Pharmacy and Therapeutics
S MarinM Solsona

Abstract

Beta-lactam antibiotic (BLA) therapy is frequently needed to treat infective endocarditis (IE). Hypersensitive reactions to BLA restrict BLA therapy in allergic patients. In the current case, we aim to describe the utility of desensitization (DS) in this context. Although the evidence is limited, DS is recommended. This case report deals with a 79-year-old woman with a clinical suspicion of allergy to BLA and a methicillin-sensitive Staphylococcus aureus (MSSA) IE. A cloxacillin DS protocol was developed to enable treatment with cloxacillin. Alternative antibiotic treatments may be less effective or not available in MSSA IE. In this case report, DS allowed optimal cloxacillin treatment.

References

Mar 24, 2004·Circulation·Vivian H ChuAndrew Wang
Apr 3, 2007·The American Journal of Medicine·José Alberto San RománFrancisco Fernández-Avilés
Sep 14, 2007·Scandinavian Journal of Infectious Diseases·François DelahayeUNKNOWN AEPEI Group
Sep 11, 2009·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Henry J LegereMariana C Castells
Aug 19, 2010·Allergy·J R CernadasUNKNOWN European Network of Drug Allergy and the EAACI interest group on drug hypersensitivity
Oct 11, 2011·The Journal of Allergy and Clinical Immunology·Andreas J Bircher, Kathrin Scherer Hofmeier
Feb 10, 2012·Lancet·Franck ThunyDidier Raoult
Nov 6, 2013·The Journal of Allergy and Clinical Immunology·Eric Macy, Richard Contreras
Dec 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Davey P LegendreEdwin Swiatlo
Apr 5, 2014·Allergy·P DemolyB Y- H Thong
Oct 5, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Roland Solensky

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Citations

Nov 26, 2021·Journal of Clinical Pharmacy and Therapeutics·Rubén González-GarcíaCarmen López-Cabezas

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