PMID: 7021491Mar 1, 1981Paper

Successful engraftment of NA1 positive bone marrow in a patient with a neutrophil antibody, anti-NA1

Human Immunology
P I WarkentinJ McCullough

Abstract

An 11-yr, 9-mo-old girl with a 5-hr history of severe aplastic anemia unresponsive to androgen or steroid therapy was treated a bone marrow transplant from her 7-yr-old, HLA-MLC identical, APO incompatible, male sibling. Donor neutrophils were positive for the NA1 antigen. The patient's pretransplant serum contained a neutrophil specific antibody, anti-NA1, reactive against donor neutrophils, which was demonstrable by both granulocyte agglutination and granulocyte cytotoxicity assays. The transplant preparative regimen consisted of cyclophosphamide, 50 mg/kg/day for 4 days, and total lymphoid irradiation (750 rads, 26 rads/min by 4 meV linear accelerator). A two plasma volume exchange (4,800 ml) by continuous flow centrifugation with an Aminco cell separator was performed one day prior to transplant because of ABO incompatibility. Following plasma exchange, anti-NA1 cytotoxic titer, 1:8 preexchange, was no longer detectable; anti-NA1 agglutinating titer had only decreased from 1:64 to 1:32. She experienced no adverse reaction to transplantation of 4:8 X 10(8) nucleated cells/kg. Marrow engraftment was demonstrable by Day 14 by steadily increasing leukocyte and platelet counts, red cells of donor ABO group, and bone marrow chrom...Continue Reading

References

Oct 1, 1978·Transplantation·C D BucknerE D Thomas
Sep 1, 1979·Transplantation·R A CliftB W Goodell
Jul 1, 1978·Vox Sanguinis·F W VerheugtC P Engelfriet
Apr 17, 1975·The New England Journal of Medicine·E ThomasC D Buckner
Sep 1, 1975·Southern Medical Journal·A H Ragab
Apr 1, 1975·Journal of Immunological Methods·A F Jiang, P Lalezari
May 1, 1972·The Journal of Pediatrics·L A BoxerP Lalezari
Jan 1, 1980·Annals of Internal Medicine·R StorbP L Weiden
Jan 1, 1980·British Journal of Haematology·C HershkoJ Fitchen

❮ Previous
Next ❯

Citations

Jan 1, 1993·International Journal of Clinical & Laboratory Research·T R Klumpp
Mar 1, 1991·Transfusion Medicine·R L RodwellA H Waters
Jan 23, 2008·Vox Sanguinis·J Bux
Aug 1, 1988·Tissue Antigens·M J JagerJ J van Rood
Jun 10, 2010·PloS One·John R Harp, Thandi M Onami
Aug 13, 2013·Expert Opinion on Investigational Drugs·Shigehiko MizutaniHiroshi Kobayashi
Oct 1, 1984·American Journal of Reproductive Immunology : AJRI·P R MadyasthaD H Levine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Blood Group Incompatibility

Blood group incompatibility between donor and recipient has been associated with poor transplant outcomes. Discover the latest research on blood group icompatibility here.

Related Papers

The New England Journal of Medicine
P LalezariM Santorineou
The Journal of Pediatrics
L A BoxerP Lalezari
The New England Journal of Medicine
P R Craddock
© 2021 Meta ULC. All rights reserved