Successful epidural analgesia for a vaso-occlusive crisis of sickle cell disease during pregnancy: a case report.

Journal of Anesthesia
Sören Verstraete, Rik Verstraete

Abstract

We describe a 19-year-old Cameroonian primigravid young woman with sickle cell disease who was admitted to a local hospital in Cameroon where the first author performed his internship gynecology and obstetrics. She presented at 28 weeks of gestation with severe pain in her left leg caused by a vaso-occlusive crisis. As recommended, high doses of intravenous morphine were administered, but without significant pain relief. She received a single bolus injection of 5 mg morphine, followed by a continuous infusion of 0.05 mg/kg/h during 48 h. Lumbar epidural blockade with bupivacaine combined with sufentanil successfully alleviated her severe peripheral ischemic pain induced by a vaso-occlusive crisis caused by sickle cell disease. Until now, only one case report and no clinical trials have been published concerning the use of epidural analgesia for treatment of a vaso-occlusive crisis of sickle cell anemia in a pregnant woman who is not in labor.

References

Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Feb 1, 1986·Obstetrics and Gynecology·D R PowarsP R Manning
Nov 1, 1996·Journal of Clinical Anesthesia·B I DanzerD M Thys
Aug 15, 2000·American Journal of Obstetrics and Gynecology·E A KopeckyK Amankwah
Jan 2, 2007·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Obstetrics
May 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anne-Lie SvenssonFred Nyberg
Jun 6, 2008·American Journal of Obstetrics and Gynecology·Margaret S VillersAndra H James
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalArturo J Martí-Peña
Jun 10, 2010·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shaker A MousaMohammad Qari
Jul 20, 2011·Obstetrics and Gynecology·Abigail D WinderRobert M Ehsanipoor
Sep 14, 2011·Hemoglobin·Samir K Ballas
Dec 22, 2011·British Journal of Anaesthesia·T T Horlocker

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.